Document 2782
 DOCN  M94A2782
 TI    Intensive non specific immunotherapy for AIDS.
 DT    9412
 AU    Cima M; Catapano S; NYU School of Medicine.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):226 (abstract no. PB0334). Unique
       Identifier : AIDSLINE ICA10/94369793
 AB    OBJECTIVE: To test the hypothesis that non specific intensive
       immunotherapy may be helpful in the treatment of AIDS. METHODS: Twenty
       patients with AIDS not in the terminal phase of the disease were treated
       with weekly injections of typhoid vaccine (Catapano's Protocol).
       Clinical evolution and lab parameters were evaluated at monthly
       intervals for 1 year. No other therapy for AIDS was given with the
       exception of medication for opportunistic infections. RESULTS: Clinical
       Observations: Resolution of fever and night sweats shrinking of enlarged
       lymph nodes, reduction in size and number of Kaposi's Sarcoma lesions,
       return of appetite, weight gain, resolution of fatigue and weakness,
       marked improvement in AIDS dementia. Laboratory observations: Elevation
       of the total white, lymphocytic and platelet counts, raise in
       hemoglobin, rise of CD4 count. Side effects were not significant.
       DISCUSSION AND CONCLUSIONS: Further studies of this therapeutic modality
       alone or in combination with other agents would appear warranted.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*THERAPY  Human
       *Immunotherapy, Active  Treatment Outcome  Typhoid-Paratyphoid
       Vaccines/*THERAPEUTIC USE  CLINICAL TRIAL  MEETING ABSTRACT

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