Document 2786
 DOCN  M94A2786
 TI    CD4 counts during treatment of herpes simplex infection in HIV-1
       infected children.
 DT    9412
 AU    Fomin J; Voronin E; Rakhmanova A; Popova I; Medical Academy Postgraduate
       Education, St. Petersburg, Russia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):225 (abstract no. PB0328). Unique
       Identifier : AIDSLINE ICA10/94369789
 AB    OBJECTIVE: Herpes simplex virus 1 (HSV 1) infection of skin is the most
       often clinical symptom in russian children infected HIV-1 by parenteral
       route. The aim was to examine changes in CD4 counts in the course of HSV
       1 infection in children long-term treated by Retrovir (Wellcome). We
       also wished to compare CD4 counts in patients with Retrovir+Zovirax
       (Wellcome) therapy. METHODS: From 1/1991 to 12/1992 55 children aged 4-7
       year-old with parenteral HIV-1 infection (all class P 2) were included
       in the analysis. All the patients have had clinical manifestations of
       HSV 1 infection as a recurrent vesicular lesions of cutaneous surfaces
       and were long-treated by oral Retrovir in 1-year period. HSV 1 was
       detected using DNA hybridization assay. At the same time, the sera were
       tested using ELISA methods for IgM and IgG antibodies to HSV 1. CD4
       cells were studied in children using monoclonal antibodies, flow
       cytometry and immunofluorescence test. The obtained variables were
       examined statistically (Student's criterium). RESULTS: All patients were
       divided in two groups. In G1 were 20 patients treated with Zovirax in
       dosage 1000 mg/d orally during 2 weeks. Average CD4 counts in this group
       before (18.5%-372/mm3) and after treatment (21.1%-505/mm3) were
       statistically different. In G2 group were 35 children not treated by
       Zovirax, those CD4 counts were examined before recurrence of HSV 1
       infection (21.6%-549/mm3) and after the clearing of skin
       (18.5%-372/mm3). In this group were registered progressive decline CD4
       cells after episode of HSV 1 infection. CONCLUSION: 1) Recurrent
       cutaneous HSV 1 infection in parenterally HIV-1 infected children
       4-7-year-old followed by declining CD4 cells despite of long-term
       antiretroviral therapy by Retrovir. 2) Treatment by Retrovir+Zovirax
       appeared to be more effective to increase initial CD4 count.
 DE    Acyclovir/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE  Child  Child,
       Preschool  Comparative Study  Drug Therapy, Combination  Herpes
       Simplex/*BLOOD/DRUG THERAPY/IMMUNOLOGY  Human  HIV
       Infections/*COMPLICATIONS  HIV-1  *Leukocyte Count/DRUG EFFECTS  *T4
       Lymphocytes  Zidovudine/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).