Document 2804
 DOCN  M94A2804
 TI    Inhibition of the antibody response to an HIV vaccine by maternal
       antibody.
 DT    9412
 AU    Jelonek M; Maskrey J; Steimer K; Potts B; Higgins K; Keller M;
       Harbor-UCLA Medical Center, Torrance.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):220 (abstract no. PB0308). Unique
       Identifier : AIDSLINE ICA10/94369771
 AB    We developed the murine model to assess the effects of passively
       transferred polyclonal maternal anti-rgp120 antibodies on the subsequent
       immunization of the offspring with rgp120SF2-CFA. Adult female BALB/c
       mice were immunized with native, glycosylated rgp120SF2 in complete
       Freund's adjuvant six weeks prior to mating. The offspring were then
       immunized with 100 micrograms rgp120SF2-CFA at three weeks of age. The
       anti-rgp120 IgG response was markedly suppressed for offspring of
       immunized mother mice compared to control offspring [Titer of 1543 vs.
       10,045, p < 0.0001]. Maternal immunization also profoundly inhibited the
       V3 antibody response of offspring as assessed by ELISA antibody to the
       V3 loop peptide, RP150. There was no inhibition of the response to an
       unrelated protein, hen egg-white lysozyme, by maternal anti-rgp120SF2
       antibody indicating that the inhibition of the response was antigen
       specific. Since newborns at risk for HIV will be immunized in the
       presence of either maternal or administered antibody (HIVIG, mAb or
       polyclonal Ab), alternative strategies may be required to circumvent the
       inhibition of the response to vaccination by pre-existing antibodies.
 DE    Animal  Animals, Newborn/IMMUNOLOGY  AIDS Vaccines/*IMMUNOLOGY  Female
       HIV Antibodies/*BIOSYNTHESIS/IMMUNOLOGY  HIV Envelope Protein
       gp120/*IMMUNOLOGY  HIV-1/*IMMUNOLOGY  *Immunity, Maternally-Acquired
       Immunization  Mice  Mice, Inbred BALB C  Peptide Fragments/IMMUNOLOGY
       Pregnancy  Recombinant Proteins/IMMUNOLOGY  MEETING ABSTRACT

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