Document 2816
 DOCN  M94A2816
 TI    The immunoactivetherapy for patients with positive HIV using
       glycyrrhizin.
 DT    9412
 AU    Endo Y; Faculty of Allied Medical Science, Akita, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):218 (abstract no. PB0302). Unique
       Identifier : AIDSLINE ICA10/94369759
 AB    OBJECTIVE: Six hemophiliacs with positive HIV treated with glycyrrhizin
       for 11 years. METHODS: The effects were described as the changes of 1)
       absolute lymphocyte counts; 2) CD4 counts; 3) CD8 counts and 4) CD4/CD8
       ratio. Of course, complete blood counts, liver function, determination
       of immunoglobulin and etc. were examined. 400 ml (800 units) of
       glycyrrhizin/day was infused every day. RESULTS: Absolute lymphocytes,
       CD4 and CD4/CD8 ratio elevated in all patients. 4 patients have good
       qualities of life now. In addition, glycyrrhizin could relief the bone
       marrow suppression as a side effect of AZT. DISCUSSION AND CONCLUSIONS:
       The administration of glycyrrhizin was considered to be effective to
       prevent the development to AIDS.
 DE    Acquired Immunodeficiency Syndrome/PREVENTION & CONTROL  Adjuvants,
       Immunologic/*THERAPEUTIC USE  Bone Marrow Diseases/CHEMICALLY
       INDUCED/THERAPY  CD4-CD8 Ratio  Glycyrrhetinic Acid/*ANALOGS &
       DERIVATIVES/THERAPEUTIC USE  Hemophilia/COMPLICATIONS  Human  HIV
       Infections/COMPLICATIONS/*THERAPY  Leukocyte Count  Quality of Life
       T-Lymphocytes, Cytotoxic  Treatment Outcome  T4 Lymphocytes
       Zidovudine/ADVERSE EFFECTS  MEETING ABSTRACT

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