Document 2828
 DOCN  M94A2828
 TI    The effect of red ginseng and zidovudine on HIV patients.
 DT    9412
 AU    Cho YK; Kim Y; Choi M; Kim Y; Choi B; Shin Y; Dept. of Microbiol., Univ.
       of Ulsan, Seoul, Korea.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):215 (abstract no. PB0289). Unique
       Identifier : AIDSLINE ICA10/94369747
 AB    OBJECTIVE: To assess whether Korean Red Ginseng(RG) affect the immune
       activation markers and CD4 cells in HIV seropositive individuals (HIV+),
       and has synergic effect with Zidovudine (ZDV). METHODS: HIV+ (n-145)
       were randomly selected and divided into 4 groups: no treatment (NO),
       ZDV, RG, and ZDV+RG combination(COM). CD4 cells were measured by flow
       cytometry, serum soluble CD8(sCD8) level and HIV p24 antigen by
       commercial ELISA Kits, and beta 2 microglobulin(beta 2M) by RIA Kit.
       Data were analysed by paired t-test and Chi-square test. RESULTS: Serum
       HIV p24 antigen decreased in 9 out of 13 HIV+ in COM. TABULAR DATA, SEE
       ABSTRACT VOLUME. CONCLUSIONS: KRG singly has positive effects on HIV
       individuals. Combination of KRG and ZDV has synergic effects.
 DE    beta 2-Microglobulin/ANALYSIS  Adjuvants, Immunologic/ADMINISTRATION &
       DOSAGE/PHARMACOLOGY/  *THERAPEUTIC USE  Antigens, CD8/ANALYSIS
       Comparative Study  Drug Synergism  Drugs, Chinese Herbal/ADMINISTRATION
       & DOSAGE/PHARMACOLOGY/  *THERAPEUTIC USE  *Ginseng  Human  HIV Core
       Protein p24/BLOOD  HIV Infections/DRUG THERAPY/*THERAPY  Leukocyte
       Count/DRUG EFFECTS  Lymphocyte Transformation/*DRUG EFFECTS  Plant
       Extracts/ADMINISTRATION & DOSAGE/PHARMACOLOGY/*THERAPEUTIC  USE
       Treatment Outcome  T4 Lymphocytes/*DRUG EFFECTS/IMMUNOLOGY
       Zidovudine/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE  CLINICAL TRIAL
       MEETING ABSTRACT  RANDOMIZED CONTROLLED TRIAL

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