Document 2841
 DOCN  M94A2841
 TI    Synergistic effect of recombinant CD4-immunoglobulin in combination with
       azidothymidine, dideoxyinosine and 0.5 beta-monoclonal antibody on HIV
       infection in vitro.
 DT    9412
 AU    Ushijima H; Ando S; Kitamura T; Muller WE; Dept. of Microbiology,
       Institute of Public Health, Tokyo, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):212 (abstract no. PB0277). Unique
       Identifier : AIDSLINE ICA10/94369734
 AB    OBJECTIVE: To demonstrate the combination therapy of recombinant CD4
       (rCD4) or CD4-immunoglobulin (rCD4-IgG) with other compounds is more
       effective than monotherapy in vitro. MATERIALS AND METHODS: rCD4-IgG (or
       rCD4), AZT, ddI and mouse MAb 0.5 beta (directed against the V3 loop
       region of HIV-IIIB-gp120), were kindly provided. MT-4, MOLT-4,
       MOLT-4/HIV-1, MOLT-4/HIV-2 and MOLT-4/SIV cells were used. Cell free
       infection and cell-to-cell infection were conducted by using IIIB strain
       with different combination- or mono-treatments. RESULTS: rCD4-IgG highly
       inhibited the infections of HIV-1 than those of HIV-2 and SIV. The
       combination with AZT, ddI or 0.5 beta MAb were more effective in
       treatment at cell-free infection in vitro than each respective compound
       alone. DISCUSSION: It is suggested that the combination therapy is more
       beneficial in treatment of HIV-infected patients than monotherapy,
       especially with respect to a reduction of the known side effects and the
       formation of resistant HIV strains after treatment with nucleoside
       analogues.
 DE    Animal  Antibodies, Monoclonal/*PHARMACOLOGY  Antigens,
       CD4/IMMUNOLOGY/*PHARMACOLOGY  Comparative Study
       Didanosine/*PHARMACOLOGY  Drug Synergism  Human  HIV Envelope Protein
       gp120/*IMMUNOLOGY  HIV-1/*DRUG EFFECTS/IMMUNOLOGY  HIV-2/*DRUG EFFECTS
       IgG/PHARMACOLOGY  Mice  Peptide Fragments/*IMMUNOLOGY  Recombinant
       Proteins/PHARMACOLOGY  SIV/*DRUG EFFECTS  Zidovudine/*PHARMACOLOGY
       MEETING ABSTRACT

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