Document 2860
 DOCN  M94A2860
 TI    Study of 31 acute HIV-1 infection (API).
 DT    9412
 AU    Sinicco A; Biglino A; Gioannini P; Inst. Infect. Diseases, Univ. of
       Turin, Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):208 (abstract no. PB0262). Unique
       Identifier : AIDSLINE ICA10/94369715
 AB    We directly observed 31 API and 168 asymptomatic seroconversions (AS) in
       patients (pts) who were seronegative in the previous 12 months. API was
       more frequently seen in pts who had HIV-1 through sex (chi 2 = 29.1; p =
       .00000). Api clinical aspects ranged from flu-like syndrome to
       mononucleosis-like syndrome. Two pts had a polyneuropathy and 2 a
       meningitis. At onset, all the pts were anti-HIV-1Ab (ELISA) negative and
       27/32 had serum p24Ag. Serum p24Ag was found after immune complex
       dissociation in the other pts. CD4+/CD8+ ratio was low in most pts
       because of CD8+ increase, whereas CD4+ were slightly low. NK were also
       increased. Seroconversion with ELISA occurred in a mean time of 41.7 +/-
       15.3 days. HIV-1 with rapid-high syncytium inducing phenotype was
       isolated in 4/7 pts. At the onset, in 15 pts IL-2 serum levels was low,
       soluble CD8 antigen, IL-1 beta, IFN-gamma and 5'-neopterin were
       increased. Follow-up showed significant decrease of IL-1 beta levels and
       increase of IL-6. API pts resulted significantly at higher risk of
       developing AIDS than AS (43% vs 7% at 45 months; p = .00001). On the
       basis of our results the early administration of antiviral drugs and
       IL-2 is of interest.
 DE    Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY  Antigens, CD8/ANALYSIS
       AIDS-Related Complex/BLOOD/COMPLICATIONS/*EPIDEMIOLOGY/
       MICROBIOLOGY/TRANSMISSION  Biopterin/ANALOGS & DERIVATIVES/BLOOD
       Comparative Study  Cytopathogenic Effect, Viral  Enzyme-Linked
       Immunosorbent Assay  Human  HIV Antibodies/BIOSYNTHESIS  HIV
       Seropositivity  *HIV-1/ISOLATION & PURIF  Interferon Type II/BLOOD
       Interleukin-1/BLOOD  Interleukin-2/BLOOD/DEFICIENCY  Meningitis/ETIOLOGY
       Peripheral Nervous System Diseases/ETIOLOGY  Phenotype  Prospective
       Studies  Risk Factors  Sex Behavior  MEETING ABSTRACT

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