Document 2872
 DOCN  M94A2872
 TI    Two cases of AIDS associated with hemophilia A, treated effectively by
       the concomitant use of SNMC and ddI.
 DT    9412
 AU    Mori K; Sendai Hematologic Clinic, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):205 (abstract no. PB0251). Unique
       Identifier : AIDSLINE ICA10/94369703
 AB    OBJECTIVE: We studied a combination therapy using glycyrrhizin (Stronger
       Neo-Minophagen C: SNMC) which has been shown to be effective against HIV
       at an ultra-high dose by a different mechanism from that of AZT and ddI.
       SUBJECTS AND METHODS: The patients were 43 year-old and 41 year-old
       brothers with hemophilia A complicated by AIDS. In addition to routine
       examinations (1) CD4 positive lymphocyte count and CD4/CD8 ratio (flow
       cytometry) (2) HIV antigen and HIV antibody (Dainabot Kit) were
       measured. RESULTS: HIV antigen levels decreased and changed to negative
       54 weeks in case 1 and 12 weeks in case 2 after the initiation of SNMC
       and ddI. HIV p24 antibody, which was negative before initiation of this
       therapy, became positive after 82 weeks and 14 weeks, respectively, and
       gradually increased. CD4 positive lymphocyte count also increased from
       68/microliters to 262/microliters and from 362/microliters to
       700/microliters, respectively. DISCUSSION AND CONCLUSIONS: Now, the
       patients maintained still good condition as AC at the time of 160 weeks
       and 140 weeks, respectively. We think that this favorable results were
       due to concomitant use of high-dose SNMC and ddI, as different types of
       anti-HIV drugs.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/COMPLICATIONS/*DRUG  THERAPY
       Adult  Antiviral Agents/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE  Case
       Report  Didanosine/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE  Drug
       Evaluation  Drug Therapy, Combination  Glycyrrhetinic Acid/*ANALOGS &
       DERIVATIVES/ADMINISTRATION &  DOSAGE/THERAPEUTIC USE
       Hemophilia/COMPLICATIONS  Human  HIV Antibodies/BLOOD  HIV
       Antigens/BLOOD  Leukocyte Count  Male  Treatment Outcome  T4 Lymphocytes
       MEETING ABSTRACT

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