Document 2886
 DOCN  M94A2886
 TI    HIV-1/HTLV-1 coinfection is associated with a high frequency of
       myelopathies.
 DT    9412
 AU    Harrison LH; Schechter M; Vaz BP; McArthur JC; Johns Hopkins University.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):202 (abstract no. PB0237). Unique
       Identifier : AIDSLINE ICA10/94369689
 AB    INTRODUCTION: Although in postmortem examinations myelopathies are found
       in up to 30% of HIV-1 infected patients, their clinical correlates are
       recognized far less frequently. How often myelopathies occur among
       subjects with HTLV-1 and HIV coinfection is not known. OBJECTIVE: To
       compare the frequency of clinically detectable myelopathies in patients
       with HIV/HTLV-1 coinfection and in patients infected with HIV only.
       METHODS: A sample of participants of a study of HIV/HTLV-1 coinfection
       (JAMA 1994; 271:353-357) were submitted to a thorough neurologic
       examination performed by a neurologist blinded to their HTLV-1
       serostatus. RESULTS: 13 individuals with coinfection and 44 HIV
       positive, HTLV seronegative controls (HIV single infection) were
       evaluated. The two groups were similar in terms of age, sex, CD4 count
       and CD4%. Among coinfected patients, 10 (77%) had evidence of
       myelopathy, as opposed to 7 (16%) controls (OR = 18, p = 0.0008). Among
       coinfected subjects, those with evidence of myelopathy had a higher CD4
       percentage (29%) than those without myelopathy (17%, p = 0.06).
       CONCLUSION: These data indicate that HIV/HTLV-1 coinfection is
       associated with a high frequency of clinically detectable myelopathies.
       The full spectrum of neurologic abnormalities associated with
       coinfection, as well as the pathogenesis and natural history, remain to
       be determined and warrant further investigation.
 DE    Human  HIV Infections/*COMPLICATIONS  HTLV-I Infections/*COMPLICATIONS
       Leukocyte Count  Neurologic Examination  Spinal Cord
       Diseases/*COMPLICATIONS/EPIDEMIOLOGY  Support, Non-U.S. Gov't  T4
       Lymphocytes  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).