Document 2898
 DOCN  M94A2898
 TI    Glutathione deficiency in the liver of HIV seropositive subjects.
 DT    9412
 AU    Barbarini G; Filice C; Zanaboni D; Garavelli G; Malfitano A; Brunetti E;
       Bellomo G; Dept. of Infectious Diseases IRCCS S. Matteo, Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):20 (abstract no. 052B). Unique
       Identifier : AIDSLINE ICA10/94369677
 AB    OBJECTIVE: Reduced-Glutathione (GSH) is decreased in plasma,
       epithelial-lung fluid and T lymphocytes in HIV+ patients. Because this
       deficiency may potentiate HIV replication and accelerate disease
       progression, we determined the level of this Tripeptide in the liver, to
       know if its concentration is correlated either to liver damage, either
       to HIV infection. MATERIAL AND METHODS: We performed 100 US-guided
       hepatobiopsies between Jan. 1992 and Jun. 1993 in hepatopathic patients
       (56 HIV+, 44 HIV-). GSH concentration was measured in the liver
       parenchyma by high performance liquid chromatography and scintillation
       spectrometry. RESULTS: Our data show a significative difference (p <
       0.01) in GSH level between HIV+ and HIV- patients, not linked to the
       score of hepatic failure; this difference is more significative between
       these two groups if we link it to drug abuse too. DISCUSSION: We think
       that appropriate therapeutic policy should be useful to replace GSH
       level in HIV+ patients, especially in drug addict ones because GSH
       deficiency could be one of factors influencing immunodeficiency during
       HIV infection.
 DE    Biopsy  Glutathione/ANALYSIS/*DEFICIENCY  Human  HIV
       Seropositivity/*METABOLISM  Liver/*METABOLISM/PATHOLOGY  Substance
       Abuse/METABOLISM  MEETING ABSTRACT

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