Document 2899
 DOCN  M94A2899
 TI    Effect of maternal HIV status on infant growth & survival.
 DT    9412
 AU    Boulos R; Ruff A; Coberly J; McBrien M; Halsey JD; CDS, Port-au-Prince,
       Haiti.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):20 (abstract no. 054B). Unique
       Identifier : AIDSLINE ICA10/94369676
 AB    OBJECTIVE: Although growth failure and increased mortality are common
       among HIV-infected infants, less is known about uninfected infants born
       to HIV-1 seropositive women. This study was undertaken to compare the
       growth and survival of breastfed infants born to HIV-1 seropositive and
       seronegative women. METHODS: Growth parameters were available from 137
       seropositive women and 270 seronegative women and their infants enrolled
       and followed monthly for 18 months as part of a prospective study of
       breastfeeding and HIV-1. Survival data were available for 191 infants
       born to seropositive women and 290 infants born to seronegative women.
       RESULTS: At 3 months of age, HIV-1 infected infants weighed
       significantly less than infants born to seronegative women (5.54 vs 6.05
       kg, p = 0.013) and these differences persisted through 18 months. At 18
       months uninfected infants also had significantly lower weights and
       heights than infants born to seronegative women. The survival rate at 18
       months was 41% among HIV-1 infected infants, 84% among uninfected
       infants born to seropositive women and 95% among infants born to
       seronegative women. The risk ratio of death among uninfected infants
       born to seropositive women was 3.20 (95% CD 1.61, 6.38) compared to
       infants born to seronegative women. CONCLUSIONS: Uninfected infants born
       to HIV-1 seropositive women exhibit poorer growth and survival than
       infants born to seronegative women. Additional studies to determine the
       etiology of these differences and to identify potential means of
       intervention are underway.
 DE    Adult  Body Weight  Female  Growth  Human  *HIV Seropositivity/MORTALITY
       *HIV-1  Infant, Newborn/*PHYSIOLOGY  Odds Ratio  Pregnancy  *Pregnancy
       Complications, Infectious  Prospective Studies  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).