Document 2901
 DOCN  M94A2901
 TI    Neuropsychological and neurodiagnostic by imaging (MRI-SPECT) early
       signs of AIDS dementia complex (ADC) in asymptomatic HIV-1 infected
       subjects: follow up.
 DT    9412
 AU    Rosci MA; Pigorini F; Bernabei A; Pau FM; Merigliano DE; Leonetti C; L.
       Spallanzani Hospital for Infectious Diseases, Rome, Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):199 (abstract no. PB0226). Unique
       Identifier : AIDSLINE ICA10/94369674
 AB    The objective of our study was to define the evolution of the early
       signs of AIDS Dementia Complex, shown by neuropsychological tests, SPECT
       (Single Photon Emission Computed Tomography) and MRI, at base line
       observation (AIDS, Volume 6 No. 11-1992), in asymptomatic HIV-1 infected
       subjects. We also aimed at defining the effect of antiretroviral therapy
       on these early signs. 42 out of the 95 patients studied were reevaluated
       after 6-12 months from the first visit, by psychometric tests; only 39
       out of 42 have been receiving antiretroviral therapy; 29 out of 42
       underwent SPECT exam also; 9 out of 42 have not been receiving any
       antiretroviral therapy. Our results seem to show: a) the neurological
       involvement, once the HIV-1 infection is acquired, may be precocious and
       be present for a long time in a subclinical form, detectable only by
       particular techniques; b) lacking correlation between mental decay
       degree, shown by neuropsychological tests, presence of abnormalities at
       SPECT, and immunological status (p < 0.50); c) lacking correlations
       between degree of immunological impairment and evolution of neurological
       involvement, shown by neuropsychological tests and SPECT (p < 0.50); d)
       antiretroviral treatment induce improvement in SPECT picture and in
       performance at psychometric tests not in all patients and independently
       of immunological conditions; e) worsening of all untreated subjects in
       spite of their persisting good immunological status (CD4+ cells >
       500/mmc) in SPECT imaging.
 DE    Acquired Immunodeficiency Syndrome/DRUG THERAPY  Antiviral
       Agents/THERAPEUTIC USE  AIDS Dementia Complex/*DIAGNOSIS/PSYCHOLOGY
       Follow-Up Studies  Human  *HIV-1  Magnetic Resonance Imaging  Neurologic
       Examination  Neuropsychological Tests  Tomography, Emission-Computed,
       Single-Photon  MEETING ABSTRACT

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