Document 2917
 DOCN  M94A2917
 TI    Stereotactic brain biopsy of focal intracerebral lesions in AIDS
       patients.
 DT    9412
 AU    Cosin J; Miralles P; Moreno S; Parras M; Salazar F; Bouza E; Infectious
       Diseases Unit, H.G. Maranon, Madrid, Spain.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):195 (abstract no. PB0207). Unique
       Identifier : AIDSLINE ICA10/94369658
 AB    OBJECTIVE: To determine the prevalence of different etiologies of
       intracerebral mass lesions unresponsive to empirical anti-toxoplasma
       therapy and to evaluate the efficacy and security of stereotactic brain
       biopsy. PATIENTS AND METHODS: During a period of 16 months, 23 cerebral
       stereotactic biopsies were performed to 21 patients with intracerebral
       masses. All patients had been treated against toxoplasma for at least 2
       weeks with no clinical or radiologic response. Five patients showed
       multiple lesions on CT scan and 18 patients showed a solitary lesion.
       RESULTS: A definitive diagnosis could be established in all 21 patients
       but a second biopsy was necessary in 2 patients. Diagnosis included
       Non-Hodgkin's Lymphoma (12 cases), toxoplasmosis (6 cases), PML (2
       cases), tuberculosis (1 case) and combined toxoplasmosis and
       tuberculosis (1 case). The results of brain biopsy significantly
       modified the management in all cases, and, in at least 11 patients,
       supposed a benefit for them. There were no deaths nor significant
       secondary effects after stereotactic biopsy. CONCLUSIONS: Stereotactic
       brain biopsy is safe and useful for the management of intracerebral mass
       lesions which do not respond to empirical antitoxoplasma treatment.
 DE    Acquired Immunodeficiency Syndrome/COMPLICATIONS/*PATHOLOGY
       AIDS-Related Opportunistic Infections/DIAGNOSIS/*PATHOLOGY
       Biopsy/*METHODS  Brain/*PATHOLOGY  Encephalitis/DIAGNOSIS/PATHOLOGY
       Human  Leukoencephalopathy, Progressive Multifocal/COMPLICATIONS/
       DIAGNOSIS/*PATHOLOGY  Lymphoma, AIDS-Related/DIAGNOSIS/*PATHOLOGY
       Prevalence  *Stereotaxic Techniques  Toxoplasmosis,
       Cerebral/DIAGNOSIS/*PATHOLOGY  Tuberculoma/DIAGNOSIS/PATHOLOGY  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).