Document 2921
 DOCN  M94A2921
 TI    Quality of life in people with depressive symptoms and HIV.
 DT    9412
 AU    Rubin HC; Patterson TL; Atkinson JH; Kaplan RM; Koch WL; McCutchan JA;
       Chandler JL; Grant I; UCSD.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):194 (abstract no. PB0205). Unique
       Identifier : AIDSLINE ICA10/94369654
 AB    OBJECTIVES: To explore the impact of depressive symptoms on
       health-related quality of life in people with HIV. METHODS: HIV+ (n =
       285) and HIV- (n = 84) men participating in a longitudinal cohort study
       were administered the Hamilton Depression Index (HAM-D) and the Quality
       of Well Being Scale (QWB)--a general health-related outcome measure--at
       baseline (T1) and six months later (T2). Clinically meaningful
       depression was defined as HAM-D > or = 10; t-tests and ANOVA were used
       to examine QWB scores in subgroups where in depression developed or
       resolved on follow-up. RESULTS: At T1, there is a decline in QWB scores
       among HIV+ subjects with increasing Hamilton scores (F = 21.60, p <
       0.001). Among those HIV+ subjects who developed depressive symptoms from
       T1 to T2 (n = 22), there was a decline in their QWB scores (t = 2.62, p
       = 0.016). HIV subjects who had depressive symptoms at T1 which resolved
       at T2 (n = 32), showed a rise in QWB scores (t = 2.00, p = 0.054). There
       were no significant differences in QWB scores in the group that remained
       depressed or in the group which remained symptom free between T1 and T2.
       CONCLUSIONS: The QWB appears to be a valid measure of changes in quality
       of life associated with depressive symptoms in HIV. Because of the
       morbidity associated with depressive symptoms, identification and
       treatment of mood symptoms and syndromes is an important priority.
 DE    Adaptation, Psychological  Adult  Cohort Studies  Depression/*PSYCHOLOGY
       Follow-Up Studies  Human  HIV Seronegativity  HIV
       Seropositivity/*PSYCHOLOGY  Longitudinal Studies  Male  Personality
       Inventory  *Quality of Life  *Sick Role  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).