Document 2922
 DOCN  M94A2922
 TI    Progression of nervous system dysfunction in HIV; 5 year follow-up.
 DT    9412
 AU    Hall CD; Messenheimer J; Wilkins JW; Whaley RA; Robertson WT; Radzion;
       Hall MJ; Kwock S; Donovan MK; Robertson KR; AIDS Neurologic Center,
       University of North Carolina, Chapel Hill; 27599.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):194 (abstract no. PB0203). Unique
       Identifier : AIDSLINE ICA10/94369653
 AB    OBJECTIVE: To assess the degree of nervous system involvement and the
       rate of progression of disease at different stages of HIV infection.
       METHODS: A cohort of 133 adults has been followed for up to 5 years with
       6 monthly evaluations. Evaluations include: neurologic; psychologic;
       neuropsychologic; routine and quantitative EEG; brainstem auditory,
       visual, somatosensory and cognitive evoked potentials; nerve conduction;
       autonomic testing; magnetic resonance imaging and spectroscopy; and T
       cell immune profile. RESULTS: Our 5 year follow-up continues to
       substantiate declines in all parameters in the late stages of disease.
       The changes were most profound in, but were not limited to, subjects
       with clinical dementia. In the systemically asymptomatic stages,
       statistically significant increases in latencies were found across time
       for P300 cognitive and visual evoked potentials. DISCUSSION AND
       CONCLUSIONS: There is a generalized decline in nervous system function
       in the late stages of HIV infection, which is not limited to subjects
       showing clinical dementia. Sensitive testing reveals subclinical but
       definite evidence of progressive neurologic dysfunction in the
       systemically asymptomatic stages of HIV infection.
 DE    Adult  AIDS Dementia Complex/CLASSIFICATION/*DIAGNOSIS  Female
       Follow-Up Studies  Human  HIV Infections/CLASSIFICATION/*DIAGNOSIS  Male
       Nervous System Diseases/CLASSIFICATION/*DIAGNOSIS  Neurologic
       Examination  Neuropsychological Tests  MEETING ABSTRACT

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