Document 2926
 DOCN  M94A2926
 TI    Progressive lesion of ascending sensory tracts.
 DT    9412
 AU    Husstedt IW; Grotemeyer KH; Busch H; Hoffmann U; Zidek W; Department of
       Neurology, Westf. Wilhelms-Universitat,; Munster/Germany.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):193 (abstract no. PB0201). Unique
       Identifier : AIDSLINE ICA10/94369649
 AB    OBJECTIVE: It was the aim of our study to detect whether or not the
       lesion of the ascending central and peripheral sensory tracts in
       HIV-infected patients are progressive. METHODS: 36 patients (mean age
       35.4 +/- 4.6 years, HIV-infection since 5.6 +/- 1.8 years (laboratory
       diagnosis), 9 female, 27 male) were examined clinically and by
       somatosensory evoked potentials of the median (MN) and tibial nerve (TN)
       in conventional manner (10/20 system). Investigations were repeated
       first 15 +/- 4 months later and second 29 +/- 6 months later. RESULTS:
       Clinical investigations showed an increase of findings indicating
       progressive lesion of sensory tracts (diminution of vibration,
       hypesthesia, ataxia). Neurophysiological investigations showed a
       statistical significant exponential increase (Friedman Nonparametric
       Repeated Measures Test) for latencies of evoked potentials (MN: N13,
       N19, N19-N13; TN: N21, P40, P40-N21). CONCLUSION: HIV-infection induces
       an exponential progressive degeneration of the peripheral and central
       ascending sensory pathways. These alterations cause a deterioration of
       quality of life in HIV-infected patients. It is assumed that the
       progressive lesion is of polyaetiologic nature. Besides indirectly
       promoted demyelination by HI-Virus, metabolic disturbances and
       neurotoxic factors like cytokines and deleterious viral products had to
       be discussed.
 DE    Adult  Afferent Pathways/PHYSIOPATHOLOGY  AIDS Dementia
       Complex/*DIAGNOSIS/PHYSIOPATHOLOGY  Evoked Potentials,
       Somatosensory/PHYSIOLOGY  Female  Follow-Up Studies  Human  HIV
       Infections/*DIAGNOSIS/PHYSIOPATHOLOGY  Male  Neurologic Examination
       Peripheral Nerves/PHYSIOPATHOLOGY  Reaction Time/PHYSIOLOGY  Sensation
       Disorders/*DIAGNOSIS/PHYSIOPATHOLOGY  Somatosensory
       Cortex/PHYSIOPATHOLOGY  MEETING ABSTRACT

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