Document 2934
 DOCN  M94A2934
 TI    Pathology of the central nervous system of AIDS in Japan.
 DT    9412
 AU    Funata N; Koike M; Tokyo Metropolitan Komagome Hospital, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):191 (abstract no. PB0191). Unique
       Identifier : AIDSLINE ICA10/94369641
 AB    OBJECTIVE: Autopsy cases of AIDS were reviewed to find the
       characteristic features in the pathology of the central nervous system
       (CNS) in Japanese patients. In addition, we examined the presence of
       Epstein-Barr virus (EBV) in CNS malignant lymphomas. METHODS: A
       consecutive autopsy series of 35 patients was reviewed. EBER1 in situ
       hybridization was applied to demonstrate EBV. RESULTS: HIV
       encephalopathy and vacuolar myelopathy were observed in 29% and 11%,
       respectively. Cytomegalovirus infection was the most frequent CNS
       infection (29%), followed by progressive multifocal leukoencephalopathy
       (11%) and toxoplasmosis (9%). Primary CNS lymphomas were present in 17%
       while secondary involvement by systemic lymphoma was seen in 3%. EBV
       could be detected in all cases of CNS lymphomas using in situ
       hybridization (4/4). DISCUSSION AND CONCLUSIONS: The present study
       confirms the frequent involvement of the CNS in Japanese patients with
       AIDS. The incidence of HIV encephalopathy and vacuolar myelopathy in
       Japan is not significantly different from that in other countries. It
       seems that the frequency of CNS lymphomas is higher in Japan and EBV is
       involved in pathogenesis of CNS lymphomas in AIDS.
 DE    Acquired Immunodeficiency Syndrome/*PATHOLOGY  AIDS Dementia
       Complex/*PATHOLOGY  AIDS-Related Opportunistic Infections/PATHOLOGY
       Brain/PATHOLOGY  Brain Neoplasms/*PATHOLOGY  *Herpesvirus 4,
       Human/ULTRASTRUCTURE  Human  In Situ Hybridization  Japan  Lymphoma,
       AIDS-Related/*PATHOLOGY  Spinal Cord/PATHOLOGY  Tumor Virus
       Infections/*PATHOLOGY  MEETING ABSTRACT

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