Document 2944
 DOCN  M94A2944
 TI    Preferential depletion of rectal lamina propria CD4+ lymphocytes.
 DT    9412
 AU    Clayton F; Reka S; Kotler DP; St. Luke's/Roosevelt Hosp Ctr, New York,
       NY 10025.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):189 (abstract no. PB0185). Unique
       Identifier : AIDSLINE ICA10/94369631
 AB    OBJECTIVE: To compare changes in mucosal lymphoid populations during
       disease progression. METHODS: We performed quantitative histologic and
       immunohistochemical stains in 61 subjects; 7 with CD4 > 500 (Early), 24
       with CD4 < 500 (Middle), 23 AIDS (Late), and 7 controls. Frozen rectal
       biopsies had stains for T and B lymphocytes, macrophages, and
       immunoglobulins, plus histopathology. RESULTS: The percentages and
       numbers of CD4 in lamina propria (LP) were decreased in Early, compared
       in lymphoid aggregates (LA) and blood (PBL), while CD8 percentages and
       numbers rose during disease progression. B lymphocytes, macrophages, and
       plasma cells did not vary. DISCUSSION AND CONCLUSIONS: There is
       preferential depletion of CD4 from LP during disease progression. As LP
       CD4 are memory cells while LA CD4 are naive cells, the results could
       reflect differences in susceptibility to infection or lysis. The early
       loss of LP CD4 could promote immunoregulatory defects. TABULAR DATA, SEE
       ABSTRACT VOLUME.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/PATHOLOGY
       B-Lymphocytes/IMMUNOLOGY/PATHOLOGY  Biopsy  Human
       Immunoglobulins/METABOLISM  Intestinal Mucosa/*IMMUNOLOGY/PATHOLOGY
       Leukocyte Count  Macrophages/IMMUNOLOGY/PATHOLOGY
       Rectum/*IMMUNOLOGY/PATHOLOGY  T-Lymphocytes/IMMUNOLOGY/PATHOLOGY  T4
       Lymphocytes/*IMMUNOLOGY/PATHOLOGY  MEETING ABSTRACT

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