Document 2949
 DOCN  M94A2949
 TI    Hepatobiliary disorders in HIV-patients.
 DT    9412
 AU    Verdejo J; Iniguez A; Polo R; Martinez ML; Inchaustegui L; Enriquez A;
       Gonzalez-Lahoz JM; Instituto de Salud Carlos III, Madrid, Spain.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):188 (abstract no. PB0182). Unique
       Identifier : AIDSLINE ICA10/94369626
 AB    We evaluate hepatobiliary complications and serological markers in viral
       hepatitis in a prospective study since February 1992. RESULTS: Patients
       108 (51 AIDS-CDC 1993). Average follow-up 245 days (range 60-690). Sex:
       M 81/F 27. Average age 31.8 (range 21-69). Risk group: IVDU 72,
       Homosexual 27, Heterosexual 8, Transfusion 1. We obtained the following
       results: (I) Hepatobiliary complications 92 in 78 patients (78/108:
       70.3%). Complications: chronic viral hepatitis 25 (19 HCV, 3 HBV, 1
       HCV+HBV, 1 HBV+HDV, 1 HBV+HCV+HDV); without filiation 17; mild
       alterations 14 (GPT and/or GGT < 1.5 times limit of normal); infectious
       diseases 10 (cholangitis/chole-cystitis 6, tuberculosis 3, bacteremia
       1); hepatotoxic agents 10; multiple factors 8 (HCV+Alcohol 7,
       HCV+hepatotoxic agents 1); alcoholism 1; acute viral hepatitis (HCV) 2;
       other 5 (2 angioma, 1 hepatocarcinoma, 1 cholelitiasis, 1 hydatid cyst).
       (II) Serological markers: 1) HBV: a) HBsAg+ 8% (HBeAg+ 50%)
       (Co-infection HDV 28.5%), b) HBsAg- with anti-HBc+ 72.7%, c) HCV 62.7%
       (we exclude the patients with EIA+ and a second-generation RIBA test
       indeterminate or negative). CONCLUSIONS: 1) Hepatobiliary complications
       are common in HIV-patients (71.5%). 2) chronic viral hepatitis HCV is
       the most frequent disease due to the 66.6% are IVDU. 3) In our
       experience, serological markers of HBV and HCV are detected in 81.1% (8%
       with HBsAg+) and 62.7% respectively.
 DE    Adult  Aged  AIDS-Related Opportunistic
       Infections/COMPLICATIONS/DIAGNOSIS  Biliary Tract
       Diseases/*COMPLICATIONS/DIAGNOSIS  Female  Hepatitis, Viral,
       Human/*COMPLICATIONS/DIAGNOSIS/TRANSMISSION  Human  HIV
       Infections/*COMPLICATIONS/DIAGNOSIS/TRANSMISSION  Liver
       Diseases/*COMPLICATIONS/DIAGNOSIS  Male  Middle Age  Risk Factors
       MEETING ABSTRACT

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