Document 2958
 DOCN  M94A2958
 TI    CMV gastrointestinal disease and Salmonella sepsis in AIDS.
 DT    9412
 AU    De Agostini M; Lipani F; Sinicco A; Inst. of Infect Dis, Univ. of Turin,
       Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):186 (abstract no. PB0174). Unique
       Identifier : AIDSLINE ICA10/94369617
 AB    OBJECTIVE: To describe manifestations of CMV gastrointestinal disease
       and to evaluate correlations between CMV infection and non-typhi
       Salmonella sepsis. METHODS: Retrospective chart review by clinicians
       following the patients prospectively. RESULTS: 8 AIDS patients (four
       homosexuals, three intravenous drug abusers, one heterosexual) developed
       CMV gastrointestinal disease. The patients were recovered at our
       institution for fever and abdominal discomfort. 6 patients had
       Salmonella spp (non-typhi) sepsis. Of these patients, two had intestinal
       perforation: biopsies performed during surgical operation revealed CMV
       intestinal disease, with lesions localized in the appendix in one case
       and in the caecum in the other. The other four patients were evaluated
       by endoscopy. In two of them, gastroscopy revealed large gastric
       biopsy-proven CMV ulcers. In the other two cases, large esophageal CMV
       polypoid lesions and ulcers were found. Of the last two patients, one
       was evaluated for perianal ulcers and sigmoidoscopy showed multiple CMV
       ulcers between anal tract and rectum; the other for disphagia, and
       endoscopy showed esophageal CMV ulcers. CONCLUSIONS: our observations
       suggest an association between Salmonella sepsis and active CMV
       gastrointestinal infection.
 DE    Acquired Immunodeficiency Syndrome/*PATHOLOGY  Adult  AIDS-Related
       Opportunistic Infections/*PATHOLOGY  Bacteremia/*PATHOLOGY  Biopsy
       Cytomegalovirus Infections/*PATHOLOGY  Endoscopy, Gastrointestinal
       Female  Gastric Mucosa/PATHOLOGY  Gastrointestinal Diseases/*PATHOLOGY
       Human  Intestinal Mucosa/PATHOLOGY  Intestinal Perforation/PATHOLOGY
       Male  Prospective Studies  Retrospective Studies  Salmonella
       Infections/*PATHOLOGY  MEETING ABSTRACT

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