Document 2966
 DOCN  M94A2966
 TI    Oral lesions in patients with HIV infection enrolled in CPCRA trials.
       The Terry Beirn CPCRA. Community Programs for Clinical Research on AIDS.
 DT    9412
 AU    Torres R; Tobin J; Vaughn A; Podhurst L; Bolden B; Raschella N; St.
       Vincent's Hospital, NYC.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):184 (abstract no. PB0165). Unique
       Identifier : AIDSLINE ICA10/94369609
 AB    OBJECTIVE: Oral candidiasis (OC) and hairy leukoplakia (HL) are oral
       lesions which have been shown to be markers of HIV disease progression.
       Using the Community Programs for Clinical Research on AIDS (CPCRA)
       observational and clinical trials database, this study evaluates the
       incidence and prevalence or these oral lesions and of esophageal
       candidiasis (EC) in a large sample of HIV-infected patients from
       community-based settings, in relationship to gender, race and CD4 count.
       METHODS: Using a sample of 4226 CPCRA participants followed for a median
       time period of 14 months, CD4 specific event rates (per 100 person years
       of risk) were calculated and proportional hazard regression analyses
       were performed separately for those with and without oral lesions at
       baseline. RESULTS: The incidence per 100 person-years of OC, EC and HL
       increased with declining CD4 counts. Rates for CD4 < 50, EC = 11.8, OC =
       56.5, HL = 8.3. For CD4 50-99, EC = 9.7, OC = 52.1, HL = 7.7. For CD4
       100-199, EC = 4.9, OC = 33.1 and HL = 7.0. For CD4 200+, EC = 1.9, OC =
       16.3 and HL = 3.8. The incidence of OC is substantially higher than EC
       and HL. During follow-up, 247 patients developed EC, 1208 developed OC
       and 223 developed HL. Rates of OC and HL were similar among racial
       groups, while the rate of HL was significantly higher for males than for
       females (CD4 adjusted relative risk = 0.47) p < 0.05. CONCLUSION: EC, OC
       and HL occur with increasing frequency as the CD4 count declines. The
       rate of HL was significantly higher for males than for females.
 DE    AIDS-Related Opportunistic Infections/*EPIDEMIOLOGY/IMMUNOLOGY
       Candidiasis, Oral/*EPIDEMIOLOGY/IMMUNOLOGY  Cross-Sectional Studies
       Esophagitis/*EPIDEMIOLOGY/IMMUNOLOGY  Human  HIV
       Infections/*EPIDEMIOLOGY/IMMUNOLOGY  Incidence  Leukocyte Count
       Leukoplakia, Hairy/*EPIDEMIOLOGY/IMMUNOLOGY  New York/EPIDEMIOLOGY
       Proportional Hazards Models  Regression Analysis  Risk Factors  T4
       Lymphocytes/IMMUNOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).