Document 2976
 DOCN  M94A2976
 TI    Ultrastructural study of oral hairy leukoplakia.
 DT    9412
 AU    Sugihara K; Yamashita S; Kagoshima University Dental School, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):181 (abstract no. PB0152). Unique
       Identifier : AIDSLINE ICA10/94369599
 AB    OBJECTIVE: The purpose of this study was to investigate the
       ultrastructure of oral hairy leukoplakia (HL) in HIV-positive
       hemophiliacs in Japan. METHODS: Biopsy specimens for the ultrathin
       sectioning were taken from HL developed in the lateral border of the
       tongue of two HIV-positive hemophiliacs. RESULTS: Disappearance of
       nuclear membrane and punched-out appearance of the condensed chromatin
       of koilocytotic cells were observed in the keratinocytes. Epstein-Barr
       virus (EBV) particles were present in the nuclei and the extracellular
       spaces in the upper two thirds of the epithelium. In the nucleoplasm EBV
       capsids in different stages of assembly were densely packed. DISCUSSION
       AND CONCLUSIONS: EBV has been identified in HL lesions in HIV-positive
       patients in several studies. In the present study EBV particles were
       observed in HL lesions developed in the lateral tongue of two
       HIV-positive hemophiliacs in Japan.
 DE    Hemophilia/*PATHOLOGY  *Herpesvirus 4, Human/ISOLATION &
       PURIF/ULTRASTRUCTURE  Human  HIV Seropositivity/*PATHOLOGY  Inclusion
       Bodies, Viral/*ULTRASTRUCTURE  Leukoplakia, Hairy/*ULTRASTRUCTURE
       Microscopy, Electron  Tongue/PATHOLOGY  Tongue Neoplasms/*ULTRASTRUCTURE
       Tumor Virus Infections/*PATHOLOGY  MEETING ABSTRACT

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