Document 3002
 DOCN  M94A3002
 TI    Oral non-Hodgkin's lymphoma (ONHL) in 7 HIV-positive homosexual males.
 DT    9412
 AU    Lozada-Nur F; Silverman S; Univ. of Calif., S.F.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):176 (abstract no. PB0131). Unique
       Identifier : AIDSLINE ICA10/94369573
 AB    Non-Hodgkin's lymphoma (NHL) has emerged as a major sequela of HIV
       infection. As patient life expectancy increases due to early
       intervention with multiple drug therapies for HIV infection, there has
       been a significant increase in the occurrence of NHL and ONHL.
       Recognition is difficult since ONHL can appear similar to mycotic
       infections, dental infections and salivary gland tumors. ONHL is very
       aggressive, therefore, early diagnosis and treatment is important. Our
       cases illustrate the clinical presentation and treatment approach in
       seven patients with ONHL. Patient characteristics: age at onset (35-55);
       the maxilla was the most common site (6 out of 7); all patients
       experienced severe pain; all patients had received therapy with AZT from
       9 to 60 months; all patients had oral candidiasis. Aggressive multiple
       cytotoxic drug therapy was the standard form of treatment. Common side
       effects were fatigue, nausea, weight loss, weakness and neutropenia.
       Radiation therapy for ONHL was added in 2 patients. Survival times
       ranged from 5 to 18 months. This is the largest reported series of ONHL.
 DE    Adult  Antineoplastic Agents, Combined/THERAPEUTIC USE  Combined
       Modality Therapy  Follow-Up Studies  *Homosexuality  Human  HIV
       Seropositivity/*DIAGNOSIS/DRUG THERAPY/MORTALITY  Lymphoma,
       AIDS-Related/*DIAGNOSIS/DRUG THERAPY/MORTALITY  Male  Middle Age  Mouth
       Neoplasms/*DIAGNOSIS/DRUG THERAPY/MORTALITY  Survival Rate
       Zidovudine/THERAPEUTIC USE  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).