Document 3005
 DOCN  M94A3005
 TI    Multiple coin lesions revealing a primary pulmonary lymphoma in a
       patient with AIDS.
 DT    9412
 AU    Allegre T; Cailleres S; Tadrist Z; Leprince Y; Jarry JM; Sault MC; Blanc
       AP; Hopital Cezanne, Aix-en-provence, France.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):175 (abstract no. PB0128). Unique
       Identifier : AIDSLINE ICA10/94369570
 AB    Pulmonary lymphoma is rarely reported in AIDS patients. A 28 year old
       HIV infected male was admitted to the hospital with dyspnea, cough, and
       fever. He was intravenous drug user and his past history was remarkable
       for pneumocystis carini pneumonia; The CD4 positive cell count was
       16/mm3.X-ray film of the chest showed multiple bilateral pulmonary
       nodules; Computed tomographic scan revealed also many lung nodules.
       Biopsy specimen was obtained by thoracoscopy and revealed a high grade
       polymorphic non Hodgkin's lymphoma of B cell type; the search of viral
       protein in the tumor showed existence of latent membrane proteins of
       Epstein Barr virus (EBV): LMP1 and EBNA2. Other radiological
       investigations, bone marrow biopsy were negative. Patient were treated
       with combined chemotherapy including adriamycin, cyclophosphamide,
       vincristine, methotrexate, and steroid, without success; he died ten
       months later after diagnosis of lymphoma. Lymphoma, the most prevalent
       HIV releated neoplasm after Kaposi's sarcoma, occurs in four to ten
       percent of patients with HIV disease, and .EBV seems to be associated in
       many cases. The most frequent sites after nodals involvement are: the
       central nervous system, the gastro intestinal tract, the liver and the
       bone marrow. Pulmonary involvement has been reported in less than ten
       percent of cases.
 DE    Adult  Antineoplastic Agents, Combined/THERAPEUTIC USE  Biopsy  Case
       Report  Coin Lesion, Pulmonary/*DIAGNOSIS/DRUG THERAPY/PATHOLOGY
       Diagnosis, Differential  Fatal Outcome  Herpesvirus 4, Human  Human
       Lung/PATHOLOGY  Lung Neoplasms/*DIAGNOSIS/DRUG THERAPY/PATHOLOGY
       Lymphoma, AIDS-Related/*DIAGNOSIS/DRUG THERAPY/PATHOLOGY  Male
       Pneumonia, Pneumocystis carinii/DIAGNOSIS/DRUG THERAPY/PATHOLOGY  Tumor
       Virus Infections/DIAGNOSIS/DRUG THERAPY/PATHOLOGY  MEETING ABSTRACT

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