Document 3007
 DOCN  M94A3007
 TI    EBV type A and B association with primary CNS lymphomas.
 DT    9412
 AU    Ciardi M; Del Re V; Toma L; Fedele CG; Cirelli A; Sorice F; Dept.
       Infectious Diseases, La Sapienza University, Rome, Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):175 (abstract no. PB0125). Unique
       Identifier : AIDSLINE ICA10/94369568
 AB    OBJECTIVE: Epstein-Barr virus (EBV) is often associated with HIV
       infection and seems to play a pathogenic role on AIDS-related primary
       lymphomas of the central nervous system (CNS); in fact EBV virus has
       been detected in both brain tissue by in situ hybriditation and
       cerebrospinal fluid (CSF) by polymerase chain reaction (PCR) in HIV
       patients affected by primary CNS limphoma. It has been shown that there
       are two EBV strains, type A and B, but until now neither type seems to
       have a specific disease association. METHODS: We performed PCR to detect
       type A and B EBV-DNA using different sets of specific primers on CSFs of
       five AIDS patients with primary CNS lymphoma. We tested previously these
       CSFs for EBV-DNA by a nested PCR using other primers. RESULTS: All 5
       patients affected by primary CNS lymphoma were positive for EBV-DNA;
       four out of 5 showed positivity for type A EBV-DNA and 1 for type B.
       DISCUSSION AND CONCLUSIONS: We noted a high prevalence of type A EBV-DNA
       in primary CNS limphomas; that could be due to geographical distribution
       but we think that there is a possibility that type A EBV could be more
       strictly associated with primary CNS limphomas than type B. Further
       studies will be required to establish if there is a difference of
       prevalence between type A and B EBV in other lymphoproliferative
       diseases in HIV patients.
 DE    Brain/MICROBIOLOGY  Brain Neoplasms/*MICROBIOLOGY  DNA, Viral/*GENETICS
       Herpesvirus 4, Human/CLASSIFICATION/*GENETICS  Human  Lymphoma,
       AIDS-Related/*MICROBIOLOGY  Polymerase Chain Reaction/METHODS  Tumor
       Virus Infections/*MICROBIOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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