Document 3008
 DOCN  M94A3008
 TI    Response to sublingual alfa interferon in Kaposi's sarcoma.
 DT    9412
 AU    Lanjewar DN; Shetty CR; Shroff HJ; Hira SK; Grant Medical College,
       Bombay, India.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):174 (abstract no. PB0124). Unique
       Identifier : AIDSLINE ICA10/94369567
 AB    OBJECTIVE: To determine 1) therapeutic response of sublingual alfa
       interferon, 2) the cause of death in case of AIDS-associated Kaposis
       sarcoma. METHODS: An autopsy study was carried out on a 35 year old
       female who presented with large papulonodular lesions on extremities for
       which she was treated with sublingual alfa interferon. RESULTS: Autopsy
       revealed disappearance of lesions of Kaposi's sarcoma over extremities.
       Microscopic lesions of KS were noted in tongue, epiglottis, lung,
       stomach, intestine and pancreas. Disseminated mycobacterial infection
       was noted in lungs, lymph nodes, liver, spleen, kidney, adrenals and
       uterus. DISCUSSION AND CONCLUSIONS: The lesions of Kaposi's sarcoma on
       skin regressed with sublingual alfa interferon. However microscopic
       lesions of KS were noted. The cause of death was due to disseminated
       mycobacteriosis. Larger clinical trials with sublingual alfa interferon
       in addition to management of associated opportunistic infections is
       recommended.
 DE    Acquired Immunodeficiency Syndrome/MORTALITY/PATHOLOGY/*THERAPY
       Administration, Sublingual  Adult  AIDS-Related Opportunistic
       Infections/MORTALITY/PATHOLOGY  Cause of Death  Female  Human
       Interferon Alfa, Recombinant/*ADMINISTRATION & DOSAGE  Neoplasms, Second
       Primary/MORTALITY/PATHOLOGY/THERAPY  Sarcoma,
       Kaposi's/MORTALITY/PATHOLOGY/*THERAPY  Skin/PATHOLOGY  Skin
       Neoplasms/MORTALITY/PATHOLOGY/*THERAPY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).