Document 3016
 DOCN  M94A3016
 TI    Serum hyaluronan in HIV and in AIDS related Kaposi's sarcoma.
 DT    9412
 AU    Blum L; Guechot J; Picard O; Cabane J; Giboudeau J; Imbert JC; Intern
       Med Dept, St Antoine Hosp, Paris, France.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):172 (abstract no. PB0113). Unique
       Identifier : AIDSLINE ICA10/94369559
 AB    OBJECTIVES: Hyaluronan (hyaluronic acid, HA) is synthesized by
       mesenchymal cells, activated by growth factors and cytokines (EGF, PDGF,
       TGF beta, IGF-1, IL1). Kaposi's sarcoma (KS) is a tumor of mesenchymal
       origin, and data suggest that the induction of the lesions involves a
       pathway of events mediated by cytokines. We tested the hypothesis that
       HA synthesis might be activated and serum HA levels increased in HIV
       patients, particulary in those with associated KS. METHODS: We measured
       serum HA levels in normal subjects (n = 40), in asymptomatic (n = 61),
       in symptomatic HIV patients (n = 12), in patients with AIDS related KS
       (n = 11). In two patients with KS receiving a chemotherapy, serum HA was
       determined monthly for 6 months. RESULTS: We found no significant
       difference in serum HA in asymptomatic HIV patients (39 +/- 26
       micrograms/l) when compared with normal subjects (32 +/- 29
       micrograms/l). Serum HA was significantly increased in patients with
       AIDS related KS (317 +/- 299 micrograms/l) and in symptomatic HIV
       patients (215 +/- 127 micrograms/l), p < 0,01. In one patient with
       cutaneous KS which received chemotherapy serum HA decreased from 542
       micrograms/l before treatment to 181 and 215 micrograms/l, (at 2 and 4
       months) when there was clinical improvement. Later, as the KS
       progressed, HA increased to 658 micrograms/l at 6 months. In the other
       patient with visceral KS serum HA increased (137 to > 1000 micrograms/l)
       as the tumour progressed according to the CT scan. CONCLUSIONS: Serum HA
       levels are increased in symptomatic HIV patients, particularly in those
       with associated KS. HA might be a useful tool to monitor the treatment
       of KS.
 DE    Acquired Immunodeficiency Syndrome/*BLOOD  Follow-Up Studies  Human
       Hyaluronic Acid/*BLOOD  HIV Infections/*BLOOD  Sarcoma,
       Kaposi's/*BLOOD/DRUG THERAPY  Skin Neoplasms/*BLOOD/DRUG THERAPY
       Treatment Outcome  Tumor Markers, Biological/*BLOOD  MEETING ABSTRACT

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