Document 3020
 DOCN  M94A3020
 TI    Protein-losing enteropathy developing in an AIDS patient with duodenal
       Kaposi's sarcoma.
 DT    9412
 AU    Takechi A; Masuda G; Ajisawa A; Negishi M; Yamaguchi T; Yamada Y; Fujii
       H; Tokyo Metropolitan Komagome Hospital.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):171 (abstract no. PB0109). Unique
       Identifier : AIDSLINE ICA10/94369555
 AB    A Japanese homosexual, HIV-positive man aged in his 30s was admitted to
       Tokyo Metropolitan Komagome Hospital in the fall of 1992. He had been
       presenting with Kaposi's sarcoma (KS) persisting over his body surface a
       year before the admission. His general condition was good. Blood data
       included: WBCs 7,000/microliters; CD4+cells 59/microliters; total
       protein 4.5 g/dl; albumin 1.8 g/dl; and his liver enzyme values were
       normal. Serum total protein and albumin progressively decreased, and he
       returned with pitting edema and bilateral transudative pleural effusion.
       Albuminuria was not demonstrated. Despite repeated IV administration of
       human albumin, his serum protein level remained low. Upper GI tract
       endoscopy demonstrated multiple small polypoid lesions in the 2nd and
       3rd parts of the duodenum. They were reddish and sessile. Biopsied
       specimens of the lesions revealed KS with villous atrophy and lymphatic
       dilatation. With the use of 99mTc -HSA-D (human serum albumin)
       scintigraphy, protein loss from the site of duodenal KS was established.
       Stool specimens were negative for occult blood, ova, parasites and
       pathogenic bacteria. After obtaining his informed consent, radiotherapy
       with a total of 30 Gy was performed. Two months later, his general
       condition became improved requiring no further albumin replacement.
       Follow-up 99mTc-HSA-D studies indicated a decreased loss of albumin into
       the duodenal lumen. Endoscopic and roentgenologic studies also
       demonstrated improved duodenal KS. The patient eventually died of
       cryptococcal meningitis ten months after his admission to our hospital.
 DE    Adult  Case Report  Diagnosis, Differential  Duodenal
       Neoplasms/*COMPLICATIONS/RADIONUCLIDE IMAGING/  RADIOTHERAPY  Follow-Up
       Studies  Human  HIV Seropositivity/*COMPLICATIONS/RADIONUCLIDE IMAGING
       Japan  Male  Protein-Losing Enteropathies/*ETIOLOGY/RADIONUCLIDE
       IMAGING/  RADIOTHERAPY  Radiotherapy Dosage  Sarcoma,
       Kaposi's/*COMPLICATIONS/RADIONUCLIDE IMAGING/  RADIOTHERAPY  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).