Document 3022
 DOCN  M94A3022
 TI    Improvement in diagnosis of visceral Kaposi-sarcoma by endoscopic
       ultrasound (EUS).
 DT    9412
 AU    Goebel FD; Bogner JR; Liess H; Zoller WG; Medizinische Poliklinik,
       University of Munich, Germany.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):171 (abstract no. PB0111). Unique
       Identifier : AIDSLINE ICA10/94369553
 AB    OBJECTIVE: Almost 50% of the patients with AIDS and Kaposi Sarcoma (KS)
       as the most frequently occurring tumor show visceral involvement.
       Gastrointestinal KS usually is diagnosed using endoscopy. To evaluate
       the use of Endoscopic Ultrasound as a complementary method scans were
       performed to assess informations about distribution pattern and
       anatomical relation to mucosa, submucosa and muscularis propria.
       METHODS/PATIENTS: 22 homosexual pts. (aged 41 +/- 9 years) were enrolled
       prospectively during a 12-months recruitment period. Endoscopy and EUS
       was performed in each patient. RESULTS: Physical examination and
       inspection of the oral cavity revealed mucocutaneous KS in 21 pts.,
       including 10 pts. with palatinal KS. Endoscopy showed lesions in 13
       pts., usually of nodular character. One patient who produced GI-symptoms
       showed KS in the stomach exclusively. Additional EUS detected 60 lesions
       suggestive of KS in 19 pts.: n = 9 esophagus, n = 10 cardia, n = 9
       fundus, n = 10 corpus, n = 8 antrum, n = 8 bulbus duodeni and n = 6 pars
       desc. duodeni. 63% of the lesions seen by EUS (38/60) presented with
       involvement of mucosa and submucosa while 16.7% (10/60) showed lesions
       throughout all three layers. 20% of the lesions (12/60) solely involved
       submucosa and muscularis propria. These lesions were not visible in
       endoscopy. Sonomorphologically they showed a similar pattern to those
       seen in endoscopy and EUS. CONCLUSIONS: These results support the
       hypothesis, that EUS provides information on KS involvement of different
       tissue layers in the GI-tract. A higher number of lesions is detected by
       EUS as compared to endoscopy. This is due to visualization of tumors
       which do not involve the mucosa and therefore evade endoscopic
       diagnosis.
 DE    Acquired Immunodeficiency Syndrome/*ULTRASONOGRAPHY  Adult  *Endoscopy,
       Gastrointestinal  Gastrointestinal Neoplasms/*ULTRASONOGRAPHY
       Homosexuality  Human  Male  Middle Age  Prospective Studies  Sarcoma,
       Kaposi's/*ULTRASONOGRAPHY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).