Document 3024
 DOCN  M94A3024
 TI    On the epidemiologic association between endemic Kaposi's sarcoma and
       malaria.
 DT    9412
 AU    Baumann S; Geier SA; Noehl MA; Goebel FD; Medizinische Poliklinik, LMU,
       Munich, Germany.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):170 (abstract no. PB0107). Unique
       Identifier : AIDSLINE ICA10/94369551
 AB    OBJECTIVE: Kaposi's sarcoma (KS) is a frequent tumor in subsaharan
       Africa (= endemic KS), and in patients with the acquired
       immunodeficiency syndrome (= AIDS-associated KS). Endemic KS has been
       attributed to environmental factors. The purpose of this study was to
       look for an association between endemic KS and malaria. PATIENTS AND
       METHODS: The literature was reviewed for data on proportional rates of
       endemic KS in Africa. The presence of malaria transmission (yes versus
       no) in countries in which data on KS were available was obtained from
       the WHO. RESULTS: In 27 African countries data on the proportional rates
       of endemic KS (range 0.04 per cent to 12.8 per cent) were available. The
       proportional rate of KS in African countries was significantly
       associated with the presence of malaria transmission (r = 0.44; p =
       0.01). CONCLUSION: These data demonstrate a geographical association
       between endemic KS and malaria. Therefore, malaria-induced
       immunosuppression might be an additional cofactor in the pathogenesis of
       endemic KS. In addition, abnormalities of cell-adhesion observed as
       blood-flow sludging in patients with AIDS-associated KS as well as in
       patients with malaria might contribute to the pathogenesis of both
       AIDS-associated and endemic KS. It furthermore might become feasible
       that the putative KS infectious agent is arthropod-borne in Africa.
 DE    Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY  Africa South of the
       Sahara/EPIDEMIOLOGY  Causality  Cross-Sectional Studies  Human
       Incidence  Malaria/*EPIDEMIOLOGY  Sarcoma, Kaposi's/*EPIDEMIOLOGY  Skin
       Neoplasms/*EPIDEMIOLOGY  Support, Non-U.S. Gov't  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).