Document 3025
 DOCN  M94A3025
 TI    Kaposi's sarcoma (KS) epidemiology in a public hospital district,
       Houston, TX.
 DT    9412
 AU    Shandera WX; Wilson J; Ben Taub Hospital, Baylor College of Medicine,
       Houston, TX 77030.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):170 (abstract no. PB0105). Unique
       Identifier : AIDSLINE ICA10/94369550
 AB    OBJECTIVE: To assess KS epidemiology among patients treated in Harris
       County Hospital District. METHODS: A retrospective review of demographic
       and clinical variables, among all AIDS patients with KS, treated between
       1987 and 1994, identified by coding and surveillance data. RESULTS: Of
       286 possible cases, 225 records were available by 2/25/94 (6-10% of all
       pts). Study group included 223 men, was largely white (63%) and
       homosexual (81%). Median age at KS diagnosis was 34, at HIV diagnosis 32
       (interval median, 14 months). KS was AIDS-defining dx in 44%. Median CD4
       count at diagnosis was 32/mm3. KS was disseminated at dx in 43%, limited
       in 36%. Recent cases (after 1/91) were more often nonwhite (p = 0.03),
       associated with nonsexual HIV transmission (p = 0.02) and had oral
       lesions (p 0.05). Best clinical responses were with intralesional
       interferon (79% complete or partial responses), vincristine/vinblastine
       (55%), or adriamycin/vinblastine/bleomycin (48%). DISCUSSION AND
       CONCLUSIONS: KS occurs in 6-10% of all AIDS patients treated in our
       public hospital district, is often AIDS-defining, and presents with CD4
       lymphopenia. Its epidemiology has changed with time. Certain
       chemotherapy regimens are associated with good responses.
 DE    Acquired Immunodeficiency Syndrome/DRUG THERAPY/EPIDEMIOLOGY/
       IMMUNOLOGY  Adult  Antineoplastic Agents, Combined/THERAPEUTIC USE
       Cross-Sectional Studies  Female  Homosexuality  Hospitals, Public
       Hospitals, Urban  Human  HIV Infections/DRUG
       THERAPY/*EPIDEMIOLOGY/IMMUNOLOGY  Incidence  Leukocyte Count  Male
       Population Surveillance  Retrospective Studies  Sarcoma, Kaposi's/DRUG
       THERAPY/*EPIDEMIOLOGY/IMMUNOLOGY  Skin Neoplasms/DRUG
       THERAPY/*EPIDEMIOLOGY/IMMUNOLOGY  Texas/EPIDEMIOLOGY  T4
       Lymphocytes/IMMUNOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).