Document 3033
 DOCN  M94A3033
 TI    Ultrastructure of nuclear bodies in Kaposi's sarcoma associated AIDS.
 DT    9412
 AU    Oyafuso LK; Hayashi H; Hotta Y; Inst. Infect. Emilio Ribas, S. Paulo,
       Brazil.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):169 (abstract no. PB0103). Unique
       Identifier : AIDSLINE ICA10/94369542
 AB    OBJECTIVES: To evaluate the morphological and ultra-structure alteration
       of the cells composing the SK lesion. Nuclear bodies could be seen in
       spindle-cell and undifferentiated endothelial cell as intranuclear
       structures. METHODS: Biopsies from AIDS associated Kaposi's sarcoma were
       obtained from 11 patients not previously treated for KS, and not having
       opportunistic infection at the time of biopsy. The skin fragments of
       Kaposi's sarcoma were processed as usually for light and electron
       microscopy. RESULTS: Light microscopy showed typical hysthopathology for
       KS. Electron-microscopy studies has shown the presence of nuclear bodies
       in spindle-like cells and undifferentiated endothelial cells from two
       patients. Both patients who had showed nuclear bodies were men,
       homosexual at the age of 25 and 31 years. The lesions were typical skin
       nodules involving the trunk. These intracellular structures were seen as
       spherical particles measuring 0.8 to 1.2 micrometer in diameter. At
       higher magnification they looked like a spiral array of double membrane.
       CONCLUSIONS: Nuclear bodies are old organelles described 30 years ago.
       Its role however is yet to discovered, but it has been associated with
       the degree of cellular activity after some kind of stimulus.
 DE    Acquired Immunodeficiency Syndrome/*PATHOLOGY  Adult  Biopsy  Cell
       Nucleus/*ULTRASTRUCTURE  Endothelium, Vascular/PATHOLOGY  Homosexuality
       Human  Inclusion Bodies/*ULTRASTRUCTURE  Male  Microscopy, Electron
       Sarcoma, Kaposi's/*ULTRASTRUCTURE  Skin/PATHOLOGY  Skin
       Neoplasms/*ULTRASTRUCTURE  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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