Document 3034
 DOCN  M94A3034
 TI    Serologic and viral correlates of HIV-1 disease progression; a
       multicenter AIDS cohort report. MACS Study. Multicenter AIDS Cohort
       Study.
 DT    9412
 AU    Black C; Farzadegan H; Henrard D; Saah A; Renaldo C; Detel R; Phair J;
       Johns Hopkins University, Baltimore, MD 21205.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):169 (abstract no. PB0102). Unique
       Identifier : AIDSLINE ICA10/94369541
 AB    OBJECTIVE: To compare HIV viral RNA and P24 antigen as well as hemoral
       response to the infection among seroconverters (SC) who developed AIDS
       in less than 3 years with SC who did not develop AIDS. Seroprevalents
       (SP) with no CD4 decline in 7 years of follow up were also used as
       control. METHOD: 17 SCs who developed AIDS in 3 years, 42 SCs who were
       AIDS free and 56 SPs with no or minimal CD4 counts were selected from
       4952 gay/bisexual men participating in Multicenter AIDS Cohort Study
       (MACS). HIV-1 P24 antigen and virion RNA as well as neoptrin, B-2
       microglobulin, Interferon X, IgG, IgM, IgA and quantitative HIV-1
       serology were performed in plasma. RESULTS: Levels of P24 antigen was
       significantly higher at first positive visit and visit closest to AIDS
       in SCs with AIDS less than 3 years. (0.02 and 0.004 respectively).
       Similarly titer of HIV RNA was 10(4.2) copies/ml and raised in rapid
       progressor as compared to 10(3.4) in non progressor and remained stable.
       Anti P24 and P17 was different in two groups (P = 0.02 and 0.0002
       respectively). Data on neopterin, B-2, Ig's and Interferon show no or
       narrow correlation. CONCLUSION: The quantitation of viral antigen and
       RNA and anti-HIV antibodies serve as predictors of progression to
       disease stage among gay/bisexual men.
 DE    beta 2-Microglobulin/METABOLISM  Acquired Immunodeficiency
       Syndrome/CLASSIFICATION/DIAGNOSIS/  *IMMUNOLOGY  Biological
       Markers/*BLOOD  Biopterin/ANALOGS & DERIVATIVES/BLOOD  Bisexuality
       Cohort Studies  Follow-Up Studies  Homosexuality  Human  HIV
       Antibodies/BLOOD  HIV Core Protein p24/BLOOD  HIV
       Seropositivity/CLASSIFICATION/DIAGNOSIS/*IMMUNOLOGY
       *HIV-1/IMMUNOLOGY/PHYSIOLOGY  Immunoglobulins/BLOOD  Interferons/BLOOD
       Leukocyte Count  Male  RNA, Viral/BLOOD  T4 Lymphocytes/IMMUNOLOGY
       Virus Replication/*IMMUNOLOGY  MEETING ABSTRACT  MULTICENTER STUDY

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