Document 3036
 DOCN  M94A3036
 TI    Is neopterin a diagnostic marker in early HIV neuromanifestations?
 DT    9412
 AU    Jandl M; Enzensberger W; Enzensberger R; Proescholdt M; Demisch L;
       Fischer PA; Dept. of Neurology, University Hosp. Frankfurt/Germany.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):168 (abstract no. PB0098). Unique
       Identifier : AIDSLINE ICA10/94369539
 AB    OBJECTIVE: Diagnosis of underlying HIV infection may be difficult in
       early neuromanifestations. In this study we tried to assess the role of
       neopterin as a further tool for detecting HIV infection. METHODS:
       Follow-up examinations in CSF and serum were performed in a female
       patient with acute meningoencephalitis before and during HIV
       seroconversion. RESULTS: HIV-ELISA, Western blot, and HIV-antigen in CSF
       and HIV-ELISA in serum were negative on day 1. However, neopterin was
       already significantly elevated in CSF (24.1 mumol/l) and serum (5.4),
       compared with normal individuals (3.5 +/- 1.7). When HIV seroconversion
       was documented by ELISA and Western blot on day 11, neopterin
       concentrations reached even higher levels (133.6 in CSF and 21.5 in
       serum). DISCUSSION AND CONCLUSIONS: Neopterin in CSF and serum may be an
       important diagnostic marker in early HIV neuromanifestations, when HIV
       testing is still negative in some cases.
 DE    AIDS Dementia Complex/*DIAGNOSIS/IMMUNOLOGY  AIDS-Related Opportunistic
       Infections/DIAGNOSIS/IMMUNOLOGY  Biopterin/*ANALOGS &
       DERIVATIVES/CEREBROSPINAL FLUID  Blotting, Western  Enzyme-Linked
       Immunosorbent Assay  Female  Follow-Up Studies  Human  HIV
       Infections/*DIAGNOSIS/IMMUNOLOGY
       Meningoencephalitis/DIAGNOSIS/IMMUNOLOGY  MEETING ABSTRACT

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