Document 3041
 DOCN  M94A3041
 TI    Serum neopterin concentration in HIV infected IVDUs.
 DT    9412
 AU    Rogowska-Szadkowska D; Borzuchowska A; Prokopowicz D; Grzeszczuk A;
       Chodynicka B; Andrzejewicz A; Rogowski F; Dep. Infect. Dis., Medical
       Sch., Bialystok, PL.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):167 (abstract no. PB0093). Unique
       Identifier : AIDSLINE ICA10/94369534
 AB    OBJECTIVE: Analysis of changes in the serum concentration of neopterin
       (NPT) in HIV infected IVDUs in relation to current using or not using
       intravenous drugs. METHODS: NPT concentrations were measured using
       radioimmunoassay (IMMUtest Neopterin-Henning Berlin) in the serum of 34
       HIV positive asymptomatic IVDUs. Twenty of them abstained from drugs for
       several months to more than a year (group A), the other 14 were active
       drug users (group B). Testing was carried out repeatedly in 3-6 months
       intervals. RESULTS: The results showed that mean NPT concentrations were
       higher than normal in both groups (A-12, 32 +/- 4, 75, B-14, 58 +/- 5,
       26 nmol/l). After 6-12 months of observation, NPT concentrations
       decreased in the group A (10, 98 +/- 2, 77 nmol/l) and significantly
       increased in the group B (23, 89 +/- 7, 7 nmol/l). CONCLUSIONS: In the
       assessment of the prognostic value of NPT concentration in HIV infected
       IVDUs the behavioral aspects must be considered.
 DE    Biopterin/*ANALOGS & DERIVATIVES/BLOOD  Follow-Up Studies  Human  HIV
       Infections/DIAGNOSIS/*IMMUNOLOGY/TRANSMISSION  HIV
       Seropositivity/DIAGNOSIS/IMMUNOLOGY/TRANSMISSION  Substance Abuse,
       Intravenous/COMPLICATIONS/*IMMUNOLOGY/  REHABILITATION  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).