Document 3043
 DOCN  M94A3043
 TI    p24 antibody level as a prognostic marker in HIV infection.
 DT    9412
 AU    Ghioni G; Fernandez E; Viglianco R; Bortolozzi R; Taborda M; Fay O;
       Center for technology in Public Health, National University of; Rosario
       Argentina.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):167 (abstract no. PB0096). Unique
       Identifier : AIDSLINE ICA10/94369532
 AB    OBJECTIVE: To evaluate the pronostic usefulness of p24 Ab cuantitation
       in HIV infection. MATERIAL AND METHODS: 61 patients HIV positive were
       included. Anti p24 from Boehringer Mannheim was ran. We used: Elisa test
       from Organon Teknika and Abbott Laboratories; confirmatory test from
       Organon Teknika (Western Blot and LiaTek), HIV antigen (with previous
       acid disociation) from Abbott Laboratories and CD4/CD8 count by IFA,
       using Boehringer Mannheim Antibody. RESULTS: In 15 (25%) out of 61
       patients the HIV Ag was positive, with a rate of 290 U/ml (50 to 550
       U/ml) anti P24 Ab < or = 7 U/ml and the rate of CD4 527/mm3 (97 to
       952/mm3) and CD8 793/mm3 (199 to 1523/mm3). In 46 (75%) patients the HIV
       Ag was negative. 30 (65%) have Anti HIV Ab titer < or = 7.0 U/ml with
       CD4 rate 503/mm3 (70 to 866/mm3) and CD8 742/mm3 (211 to 1441/mm3). In
       16 (35%) The Anti P24 Ab was > or = 66.0 (66 to 156/mm3) with a CD4
       count 784/mm3 (630 to 1309mm3) and CD8 909/mm3 (642 to 1496mm3). Table I
       shows the comparative results of different markers. DISCUSSION AND
       CONCLUSIONS: 1) Anti p24 Ab seems to be a more releable marker than
       CD4/CD8 and HIV Ag (p < 0.05) in the progression of HIV infection.
       Whereas CD4/CD8 count remain stable, the HIV Ag level is not
       significative statistically (p < 0.05). 2) The balance between the
       shyntesys of antibody by the immune sistem and its role as a
       neutralizing antibody apparently has direct influence in the level of
       Anti HIV p24 Ab. TABULAR DATA, SEE ABSTRACT VOLUME.
 DE    Blotting, Western  CD4-CD8 Ratio  Enzyme-Linked Immunosorbent Assay
       Human  HIV Antibodies/*BLOOD  HIV Antigens/BLOOD  HIV Core Protein
       p24/*IMMUNOLOGY  HIV Infections/*DIAGNOSIS/IMMUNOLOGY  HIV
       Seropositivity/DIAGNOSIS/IMMUNOLOGY  Leukocyte Count  Prognosis  T4
       Lymphocytes/IMMUNOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).