Document 3045
 DOCN  M94A3045
 TI    Natural killer (NK) cells in HIV disease.
 DT    9412
 AU    Whitelaw J; Brettle R; Scott G; Robertson R
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):166 (abstract no. PB0091). Unique
       Identifier : AIDSLINE ICA10/94369530
 AB    OBJECTIVE: The aim of the study was to look at the concentration of
       Natural Killer (NK) cells in two risk groups infected with HIV 50
       intra-venous drug users were analysed and 50 homo/bisexual men were the
       second cohort. METHOD: Blood was incubated with dual labelled monoclonal
       antibodies as follows- 1. lymphocyte gating MoAb CD45/14 2. isotype
       control and 3. T-cell and NK marker CD3/16 + 56 (Becton Dickinson) The
       red blood cells were lysed and the remaining cells analysed by flow
       cytometery--FACScan (Becton Dickinson). RESULTS: The average of the 50
       IVDU (38 male:12 female) was 6.8% positive staining for CD16 + 45 in the
       lymphocyte 'gate'. In the sexually aquired cohort the mean was 15.7% of
       similar cells. DISCUSSION: NK cells are reported to exhibit minimal
       specificity and have no memory. Their cell lineage is not known. Also
       they are non-adherent and non-phogocytic. The above results show a
       marked difference in the two cohorts. Differing viral strains may be the
       agent?
 DE    Antigens, CD45/BLOOD  Bisexuality  Cohort Studies  Female  Homosexuality
       Human  HIV Infections/DIAGNOSIS/*IMMUNOLOGY/TRANSMISSION  Killer Cells,
       Natural/*IMMUNOLOGY  *Leukocyte Count  Male  Receptors, IgG/METABOLISM
       Risk Factors  Sex Behavior  Substance Abuse,
       Intravenous/COMPLICATIONS/IMMUNOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).