Document 3049
 DOCN  M94A3049
 TI    Progressive biological markers of HIV infection depending on different
       risk groups and CDC stages.
 DT    9412
 AU    Fuster M; Martinez C; Cortes M; Cadafalch J; Domingo P; Barrio J;
       Sambeat MA; Internal Medicine Department, Programa SANT PAUCITRAN,
       Hospital; de Sant Pau, Barcelona, Spain.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):165 (abstract no. PB0088). Unique
       Identifier : AIDSLINE ICA10/94369526
 AB    OBJECTIVE: To study the biological parameters of HIV progressive
       infection depending on different risk groups. METHOD: Different
       biological parameters (B2-M, neopterine, CD4 linfocites, triglicerides,
       IgA and ADA) have been studied in a sample of 524 HIV+ patients. From
       the first blood extraction the patients were divided into four different
       risk groups: 75 heterosexuals, 107 homosexuals, 220 ex IDU and 122
       active IDU. Following the CDC criteria for their classification, 360
       pacients belonged to the group II-III, 71 patients were IVc2 and 93
       patients were IVc1. The four risk groups were showing similar
       characteristics on the different stages, only statistical significant
       differences were found in the IVc2 group which was higher in the group
       of patients who had been infected by the way they took drugs (IDU).. The
       data were interrelated depending on the risk group and on the CDC stage.
       Statistical analyses were performed with the Statgraph Statistical
       Package. RESULTS: All the different parameters being studied were
       statistically significant, higher in the 93 patients belonging to the
       IVc1 group (AIDS), except for the ADA in serum which was higher in the
       IVc2 patients. Independently from the CDC stage the values for the
       B2-microglobuline were significatively higher in the group of patients
       showing an active addiction (p = 0.047); neopterine in the heterosexual
       group (p = 0.0007); ADA in the group of IDU (p = 0.0000). Neither CD4
       linfocites nor triglicerides showed any statisticaly significant
       differences. When relating these data depending on the CDC stage of
       infection: B2-microglobuline was significatively higher in the II-III
       stage in the active IDU group (P = 0.0020) and in the IVc1 stage in the
       homosexual group. Neopterine was significatively higher in the
       homosexual group depending both on the II-III stage (p = 0.0464) and in
       the IVc1 (p = 0.0014). IgA was higher in the II-III stage both in the
       heterosexual and in the homosexual groups (p = 0.0057) without any
       significant differencies depending neither on the IVc1 nor on the IVc2.
       ADA values were higher in the II-III in the active IDU(p = 0.0001) and
       no statisticaly significant difference as found neither in the group
       IVc1 nor in the IVc2. CONCLUSION: Among asymptomatic patients the B2-M
       values are higher if and active IDU addiction is present at the moment,
       while IgA values were higher in the sexual transmission groups (homo and
       heterosexual) and ADA was so in the parenteral group of risk. Neopterine
       was higher in the homosexual group through all the stages.
 DE    beta 2-Microglobulin/METABOLISM  Acquired Immunodeficiency
       Syndrome/CLASSIFICATION/DIAGNOSIS/  TRANSMISSION  Biological
       Markers/*BLOOD  Biopterin/ANALOGS & DERIVATIVES/BLOOD  Female
       Homosexuality  Human  HIV
       Infections/CLASSIFICATION/*DIAGNOSIS/TRANSMISSION  IgA/BLOOD  Leukocyte
       Count  Male  Risk Factors  Substance Abuse,
       Intravenous/COMPLICATIONS/IMMUNOLOGY  Triglycerides/BLOOD  T4
       Lymphocytes/IMMUNOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).