Document 3050
 DOCN  M94A3050
 TI    Delayed type hypersensitivity skin testing in HIV-infected persons,
       Chiangrai, Thailand.
 DT    9412
 AU    Yanai H; Uthaivoravit W; Sawanpanyalert P; Limpakarnjanarat K; Mastro
       TD; Chiangrai Health Club, Muang Chiangrai, Thailand.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):165 (abstract no. PB0086). Unique
       Identifier : AIDSLINE ICA10/94369525
 AB    OBJECTIVE: To examine the utility of delayed type hypersensitivity (DTH)
       skin tests in HIV-infected individuals in Chiangrai, northern Thailand.
       METHODS: We examined the reactivity to three DTH skin test antigens
       (PPD, Mumps, and Candida) in 201 asymptomatic HIV-infected individuals
       identified among blood donors and anonymous HIV counseling and testing
       clinic attendees; and 102 HIV-seronegative blood donors. RESULTS: Latent
       TB infection (PPD > or = 10mm induration) was common among HIV-negative
       persons: 70% among those with, and 54% among those without a BCG scar.
       Compared to HIV-negatives, HIV-positive persons had decreased (P < 0.01)
       reactivity to all three antigens: TABULAR DATA, SEE ABSTRACT VOLUME. CD4
       level and skin test reactivity show only small correlations. DISCUSSION
       AND CONCLUSIONS: Mumps and Candida are appropriate antigens for anergy
       testing in Thailand and can be used as a functional measurement of
       immunity, in addition to CD4. The high prevalence of latent TB in this
       population and decreased reactivity to PPD in HIV-seropositives support
       the provision of INH preventive therapy to all HIV-infected individuals
       in Thailand regardless of PPD results.
 DE    Antigens/DIAGNOSTIC USE/IMMUNOLOGY  Blood Donors  *Developing Countries
       Human  Hypersensitivity, Delayed/*IMMUNOLOGY  HIV
       Infections/DIAGNOSIS/*IMMUNOLOGY  HIV Seronegativity/IMMUNOLOGY
       *Intradermal Tests  Leukocyte Count  Reference Values  Thailand  T4
       Lymphocytes/IMMUNOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).