Document 3054
 DOCN  M94A3054
 TI    Association of proviral load and immune disease.
 DT    9412
 AU    Conway B; Ko DS; Dufour D; Salas T; Montpetit M; U. of Ottawa AIDS
       Research Group and Bureau of HIV/AIDS; Laboratories & Research, Ontario,
       Canada.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):164 (abstract no. PB0083). Unique
       Identifier : AIDSLINE ICA10/94369521
 AB    OBJECTIVE: To evaluate the relationship between circulating proviral
       load and the severity of immune disease. METHODS & RESULTS: Mononuclear
       cells (MCs) were isolated from 129 HIV-infected individuals and proviral
       load (copies/10(6) CD4 cells) measured by quantitative PCR. CD4 cell
       counts, in discrete categories, were taken as a measure of immune
       disease. TABULAR DATA, SEE ABSTRACT VOLUME. CONCLUSION: A clear
       association between proviral load (median & range) and immune disease
       category was observed, although the ranges remained quite broad, as we
       (and others) have previously demonstrated. When proviral load was
       examined as a categorical variable, 20/22 with > 10(4) copies/10(6)
       cells had CD4 < 200/microliters, while 27/32 with < 10(3) copies/10(6)
       cells had CD4 > 200 microliters. Further work is underway in our centre
       to determine if a threshold value for circulating proviral load could be
       used as a predictor of clinical and immunologic disease progression.
 DE    Human  HIV/*IMMUNOLOGY  HIV
       Infections/CLASSIFICATION/DIAGNOSIS/*IMMUNOLOGY
       Monocytes/IMMUNOLOGY/MICROBIOLOGY  Prognosis  Proviruses/*IMMUNOLOGY  T4
       Lymphocytes/*IMMUNOLOGY/MICROBIOLOGY  Virus Replication/IMMUNOLOGY
       MEETING ABSTRACT

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