Document 3057
 DOCN  M94A3057
 TI    Immunological markers indicating the AIDS evolution.
 DT    9412
 AU    Jauregui Rueda H; Balbaryski J; del Castillo M; Monticelli A; L.I.C.
       Laboratory Buenos Aires, Argentina.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):163 (abstract no. PB0079). Unique
       Identifier : AIDSLINE ICA10/94369518
 AB    OBJECTIVE: 1) To evaluate four immunological markers in HIV infected
       patients classificated according to the CDC classification, April 1992.
       2) To determine if some of the studied markers be of more predictive
       value in the progression of the infection. 3) The relationship between
       markers and mortality. METHODS: The records of patients with HIV
       infection attending the L.I.C. LABORATORY, Buenos Aires, Argentina were
       reviewed from January'92 to December'93. It was studied CD4+ linphocytes
       count, B2 microglobuline, Agp24 and the level of IgA in 34 patients (31
       male, 3 female; average age: 30 years old). The patients were
       classificated according to the CDC classification. RESULTS: TABULAR
       DATA, SEE ABSTRACT VOLUME. DISCUSSION AND CONCLUSIONS: 1 GROUP 1 (44%)
       did not modify his stage A1A2, presenting normal values of CD4+ abs,
       B2microglobuline, IgA level, and Agp24 not reactive. GROUP 2 (12%) made
       a progress of the infection-disease from A1A2-B1B2-C1C2 with a
       continuous decrease of CD4+ count, increase of B2microglobuline and IgA
       level, and discontinuous reactivity of Agp24. GROUP 3 (44%) made a
       progress of infection-disease to stage C3 where the CD4+ count decreased
       below 50 cell/mm3, a major increasement of B2microglobuline and IgA
       level, and reactive Agp24. 2) Linphocytes CD4+ count showed the best
       correlation with the progression of the infection. 3) In GROUP 3 the 27%
       of the patients died, not presenting any correlation between the
       parameter and the mortality date.
 DE    beta 2-Microglobulin/METABOLISM  Acquired Immunodeficiency
       Syndrome/CLASSIFICATION/*DIAGNOSIS/  IMMUNOLOGY  Adult  Argentina
       Biological Markers/*BLOOD  Female  Follow-Up Studies  Human  HIV Core
       Protein p24/BLOOD  HIV Infections/CLASSIFICATION/*DIAGNOSIS/IMMUNOLOGY
       IgA/BLOOD  Leukocyte Count  Male  T4 Lymphocytes/IMMUNOLOGY  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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