Document 3069
 DOCN  M94A3069
 TI    Progression of HIV infection from the moment of probable transmission.
 DT    9412
 AU    Meira DA; Souza LR; Marcondes-Machado J; Zacchi B; Faculdade de Medicina
       de Botucatu, UNESP, Brazil.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):160 (abstract no. PB0066). Unique
       Identifier : AIDSLINE ICA10/94369506
 AB    OBJECTIVE: In Brazil little is known about the progression of AIDS
       infection considered from the moment of transmission. The objective of
       the study was to observe this situation. METHODS: 65 HIV infected
       individuals with probable moment of contagion determined were studied,
       after a 8-year follow up period. Mechanisms of transmission were
       defined. The moment of diagnosis, onset of simptoms, last medical
       examination and death were computed. Opportunistic infections during
       follow up and at autopsy were considered. CD4+ cells were counted at
       diagnosis and last medical examination. Results were expressed through
       median values. RESULTS: One patients had acute infection three months
       after transmission and CD4+ cell count of 778/mm3. Eighteen patients
       died 65 months after contagion, with 127 CD4+/mm3. They were diagnosed
       60 months after transmission with 165 CD4+ cells/mm3. Survivors without
       opportunistic infections were diagnosed 36 months after transmission
       with 512 CD4+ cells/mm3 and were last examined one year later, with 460
       CD4+ cells/mm3. Survivors with opportunistic infections had been
       diagnosed 72 months after transmission, with 273 CD4+ cells/mm3.
       DISCUSSION AND CONCLUSIONS: Time of survival and CD4+ cells count were
       different among survivors and individuals who died, although there was
       no difference among them concerning opportunistic infections, what could
       be due to altered CD4+ cell function as well. Further studies are needed
       to categorize these patients for TH1 and TH2 type responses to assess
       CD4+ cells function.
 DE    Brazil  Follow-Up Studies  Human  HIV
       Infections/IMMUNOLOGY/MORTALITY/*TRANSMISSION  Leukocyte Count  Survival
       Rate  T4 Lymphocytes/*IMMUNOLOGY  MEETING ABSTRACT

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