Document 3070
 DOCN  M94A3070
 TI    Lymphoproliferative response correlates to the markers of HIV-infection.
 DT    9412
 AU    Markova R; Beshkov D; Argirova R; Center of Immunology, Military Medical
       Academy, Sofia, Bulgaria.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):160 (abstract no. PB0065). Unique
       Identifier : AIDSLINE ICA10/94369505
 AB    OBJECTIVE: To look for a possible correlation between
       lymphoproliferative response to phytohaemagglutinin (PHA) and
       recombinant interleukin (rIL-2) and the known markers of HIV-infection.
       METHODS: Ten HIV-infected persons (7 with AIDS and 3 asymptomatic) were
       followed-up in 3-6 month intervals. Lymphoproliferative response to PHA,
       rIL-2 and PHA+rIL-2, as well as the spontaneous blastogenesis, were
       measured in radiometric blasttransformation assay along with CD4/CD8,
       p24 Ag, anti-p24, plasma viremia and Western blot (WB) patterns.
       RESULTS: Although preliminary, our results show a correlation between
       the spontaneous blastogenesis and p24 Ag detection with progression of
       HIV infection. The value of the ratio between stimulation indices of
       PHA+rIl-2/PHA correlates to CD4, plasma viremia, WB and course of
       infection. CONCLUSION: The proposed by us ratio might be a valuable
       marker in the monitoring and prognosis of HIV-infection.
 DE    Biological Markers/*BLOOD  Blotting, Western  CD4-CD8 Ratio  Follow-Up
       Studies  Human  HIV Antibodies/BLOOD  HIV Core Protein p24/BLOOD  HIV
       Infections/DIAGNOSIS/*IMMUNOLOGY  Lymphocyte Transformation/*IMMUNOLOGY
       Viremia/IMMUNOLOGY  MEETING ABSTRACT

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