Document 3075
 DOCN  M94A3075
 TI    HIV incidence in adults in northern Thailand.
 DT    9412
 AU    Khamboonruang C; Beyrer C; Natpatan C; Eiumtrakol S; Celentano D; Nelson
       KE; Research Institute for Health Sciences, Chiang Mai University,;
       Thailand.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):16 (abstract no. 038C). Unique
       Identifier : AIDSLINE ICA10/94369500
 AB    OBJECTIVE: To measure the HIV-1 incidence, followup rates and high risk
       behaviors in cohorts of seronegative adults in northern Thailand.
       METHODS: We screened cohorts of female commercial sex workers (CSWs),
       male STD clinic pts, royal Thai Army (RTA) conscripts, and discharged
       RTA conscripts at baseline and q3-6 mos. for HIV infection by ELISA and
       WB and did interviews for high risk behavior, medical history, and STD
       cultures. RESULTS: Of 1068 CSWs 409 (38.3%) were HIV pos and 396 HIV neg
       were enrolled in the study; followup at 6 mos. was 70.7% and 19
       seroconverted for an incidence of 12.8/100 person yrs. Of 1031 male STD
       pts 164(15.9%) were HIV pos and 264 HIV neg (30.4%) were enrolled;
       followup at 6 mos was 91.9% and 6 seroconverted for an incidence of
       4.92/100 person yrs. Of 969 RTA conscripts 12.4% were HIV pos at
       baseline and 90% were followed at 6 mos; 3 of 778 seroconverted an
       incidence of 0.87/100 person yrs. (Previous RTA cohorts have had an
       incidence of 3.4%/yr.) Among 380 men discharged from RTA, followup at 9
       mos. was 81.8% and the incidence was 5.2/100 person yrs. Sample sizes
       required to show an HIV vaccine efficacy of 60%, with a power = .90,
       alpha = .05 varies from CSWs = 644, STD pts. 1,456 to ex-RTA = 1306.
       CONCLUSIONS: Several populations in northern Thailand appear to have
       sufficiently high HIV-1 incidence and adequate followup for HIV vaccine
       efficacy trials and other preventive intervention trials.
 DE    Adult  Blotting, Western  Enzyme-Linked Immunosorbent Assay  Female
       Human  HIV Infections/*EPIDEMIOLOGY/PREVENTION & CONTROL/TRANSMISSION
       HIV Seropositivity/EPIDEMIOLOGY  *HIV-1  Male  Military Personnel
       Prostitution  Risk-Taking  Sex Behavior  Sexually Transmitted
       Diseases/EPIDEMIOLOGY  Thailand/EPIDEMIOLOGY  MEETING ABSTRACT

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