Document 3079
 DOCN  M94A3079
 TI    Biological markers in the study of HIV infected and HIV non-infected
       drug abusers.
 DT    9412
 AU    Miro JM; Bedini JL; Serrano J; Filella X; Mallolas J; Lozano L; Hospital
       Clinic i Provincial, Barcelona, Spain.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):159 (abstract no. PB0061). Unique
       Identifier : AIDSLINE ICA10/94369496
 AB    PURPOSE--To stablish reference values for neopterin (NP), beta 2
       microglobulin (B2M), TNF and soluble interleukin 2 receptor (IL-2R) for
       both HIV infected assymptomatic drug abusers (HIV DA) and HIV non
       infected drug abusers (Non-HIV DA). METHODS--97 Non-HIV DA and 164 HIV
       DA were studied. HIV DA were followed periodically since 1986-87 until
       december 1991. At first visit we performed serum determinations for the
       following biological markers: NP (RIA, Immunotest Neopterin, Henning),
       B2M (RIA, Pharmacia), TNF (ELISA, Medgenix) and IL-2R (ELISA,
       Immunotech). AIDS diagnosis was performed according CDC criteria (august
       1987). Univariate and multivariate analysis were carry out with BMDP
       statistical package routines. RESULTS--Significative differences between
       HIV DA and NHIV DA were found for NP (p < 0.001), B2M (p < 0.001) and
       IL2R (p < 0.01). Non significative differences were found for TNF. 25
       out of 164 HIV DA (15%) progress to AIDS in five years. B2M > 2.9 mg/dL
       (p < 0.005) was the parameter that reflects a greater progression to
       AIDS in the univariate analysis. The multivariate analysis also
       identifies B2M > 2.9 mg/dL as the parameter with high independent
       prognostic significance (OR: 3.5, CI 95% 1.2-8.4 mg/dL, p < 0.01).
       CONCLUSIONS--Reference values for NP, B2M and IL2R are different for HIV
       DA and Non-HIV DA. High serum levels of B2M are associated with a
       greater progression to AIDS in assymptomatic HIV DA.
 DE    beta 2-Microglobulin/METABOLISM  Acquired Immunodeficiency
       Syndrome/DIAGNOSIS/IMMUNOLOGY  Adult  Biological Markers/*BLOOD
       Biopterin/ANALOGS & DERIVATIVES/BLOOD  Human  HIV
       Infections/*DIAGNOSIS/IMMUNOLOGY  Prognosis  Receptors,
       Interleukin-2/METABOLISM  Reference Values  Substance Abuse,
       Intravenous/COMPLICATIONS/*IMMUNOLOGY  Support, Non-U.S. Gov't  Tumor
       Necrosis Factor/METABOLISM  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).