Document 3080
 DOCN  M94A3080
 TI    Immune activation markers and CD4 cells counts in HIV clinical stages.
       Predictors of advanced disease?
 DT    9412
 AU    Portilla J; Sanchez J; Boix V; Munoz C; Sen ML; Reus S; Perez-Mateo M;
       Hospital General de Alicante, Spain.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):158 (abstract no. PB0058). Unique
       Identifier : AIDSLINE ICA10/94369495
 AB    OBJECTIVE: To evaluate the relationship among serum neopterin, beta 2
       microglobulin, IgG, IgA, IgM, clinical stage and CD4 lymphocyte counts.
       METHODS: In 108 HIV patients (IVDU 80%), 89 men and 19 women, we
       determined CD4 cells by flow cytometry; beta 2 microglobulin, IgG, IgA e
       IgM by immunonefelometry and serum neopterin by RIA. The patients were
       classificated according to the CDC staging system (1987): stage A (II,
       III), stage B (IVA, IVC2), stage C (case definition for AIDS, CDC 1987).
       Statistical analysis: analisis of variance, Student's t-test and
       Pearson's correlation test. TABULAR DATA, SEE ABSTRACT VOLUME. There was
       no correlation between the immune markers and the CD4 counts.
       CONCLUSIONS: 1) IgA levels are increased in advanced HIV disease. 2) IgA
       is the only immunoglobulin with prognostic value. 3) Elevations of IgA
       and serum neopterin and run down of CD4 cell counts are independents
       markers of AIDS. 4)Like others, this study shows that beta 2
       microglobulin is not a good prognostic marker when HIV patients are
       preferently IVDU.
 DE    beta 2-Microglobulin/METABOLISM  Adult  Biopterin/ANALOGS &
       DERIVATIVES/BLOOD  Human  HIV
       Infections/CLASSIFICATION/*DIAGNOSIS/IMMUNOLOGY  Immunoglobulins/BLOOD
       *Leukocyte Count  Lymphocyte Transformation/*IMMUNOLOGY  Prognosis
       Substance Abuse, Intravenous/IMMUNOLOGY  T4 Lymphocytes/*IMMUNOLOGY
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).