Document 3082
 DOCN  M94A3082
 TI    Evaluation of immuno-status in HIV disease using serum
       2'5'-oligoadenylate synthetase activity.
 DT    9412
 AU    Ueda M; Higasa S; Suehiro A; Kakishita E; 2nd Dept. of Internal
       Medicine, Hyogo College of Medicine, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):158 (abstract no. PB0060). Unique
       Identifier : AIDSLINE ICA10/94369493
 AB    OBJECTIVE: 2'5'-oligoadenylate synthetase (2-5AS) has been reported to
       be induced by interferons (IFN) and its activity in mononuclear cells
       reliably reflects activation of the IFN system by viral infections. To
       evaluated the immuno-status in HIV disease and the progression of the
       disease, serum 2-5AS activities in hemophiliacs were measured. METHODS:
       Serum 2-5AS activities in 28 hemophiliacs, fifteen HIV seropositive and
       thirteen HIV seronegative patients. The correlations between serum 2-5AS
       activity and the other conventional Aparameters for the evaluation of
       immunostatus were also examined. RESULTS: Serum 2-5AS activity in HIV
       seropositive hemophiliacs was significantly higher than in HIV
       seronegative hemophiliacs. In HIV seropositive hemophiliacs, serum 2-5AS
       activities were negatively correlated with CD4+ lymphocytes and
       CD4+/CD8+ ratio. DISCUSSION AND CONCLUSIONS: Our results showed that
       serum 2-5AS activity was elevated by HIV infection and might be useful
       marker to evaluate the immuno-status in HIV disease. Further study
       confirm the correlation between 2-5AS activity and clinical stage of HIV
       suggested to be needed.
 DE    CD4-CD8 Ratio  Hemophilia/IMMUNOLOGY  Human  HIV
       Infections/CLASSIFICATION/*IMMUNOLOGY  HIV Seronegativity/IMMUNOLOGY
       HIV Seropositivity/CLASSIFICATION/*IMMUNOLOGY  Leukocyte Count
       Prognosis  Reference Values  T4 Lymphocytes/IMMUNOLOGY
       2',5'-Oligoadenylate Synthetase/*BLOOD  MEETING ABSTRACT

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