Document 3083
 DOCN  M94A3083
 TI    Analysis of immunological parameters showed that antiretroviral
       treatment is necessary for the PGL state.
 DT    9412
 AU    Takata N; Fujii T; Dept of Internal Med. Hiroshima Univ., Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):158 (abstract no. PB0057). Unique
       Identifier : AIDSLINE ICA10/94369492
 AB    OBJECTIVE: We investigated the medical records and laboratory findings
       to find which parameters might be characteristic for the HIV disease
       progression. MATERIALS & METHODS: We compared the data of 30 patients
       with HIV infection (20 hemophiliacs and 10 pts with sexual contact; 28
       males and 2 females; 36.4 +/- 10.9 years of age; 47,841 total
       observation days; 8 ACs, 9 early ARCs, 6 late ARCs and 7 AIDSs as final
       stage) and those of 31 seronegative pts (30 male hemophiliacs and one
       female with von Willebrand disease; 40.3 +/- 15.4 years of age; 41,703
       days) as control. RESULTS: Analysis of the calculated 442 records
       confirmed the strong correlationships (p < 0.001) between the clinical
       stage and CD4+cell count, CD20+ cell count, CD16+ cell count, mitogenic
       response to PWM, beta 2 microglobulin and serum IgA, respectively. On
       the other hand, cell count of CD8+ and HLA-DR+ and CD57+ were
       significantly co-elevated at the midst of the disease course. The serum
       immunoglobulin levels increased in the different manners by the class
       and stage; IgM in the AC, IgG in the early ARC and IgA in the far more
       advanced stage. DISCUSSION & CONCLUSIONS: In the early ARC, the
       immunological fight against the enhanced viral replication is prominent.
       So the anti-retroviral therapy should be initiated no later than this
       stage.
 DE    Acquired Immunodeficiency Syndrome/DRUG THERAPY/IMMUNOLOGY/
       TRANSMISSION  Adult  Antiviral Agents/*THERAPEUTIC USE  AIDS-Related
       Complex/DRUG THERAPY/IMMUNOLOGY/TRANSMISSION  Female  Human  HIV/DRUG
       EFFECTS/IMMUNOLOGY  HIV Infections/*DRUG THERAPY/IMMUNOLOGY/TRANSMISSION
       Leukocyte Count/DRUG EFFECTS  Lymphocyte Subsets/DRUG EFFECTS/IMMUNOLOGY
       Lymphocyte Transformation/DRUG EFFECTS/IMMUNOLOGY  Male  Middle Age
       Virus Replication/*DRUG EFFECTS/IMMUNOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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