Document 3088
 DOCN  M94A3088
 TI    Soluble IL-2 receptor (sIL-2R) in seropositive individuals.
 DT    9412
 AU    Tateno Y; Takahashi T; Tateno M; Togashi T; Sato H; Yoshiki T; Dept. of
       Pediatrics, Hokkaido University, Sapporo, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):156 (abstract no. PB0050). Unique
       Identifier : AIDSLINE ICA10/94369487
 AB    OBJECTIVES: Elevated soluble IL-2 receptor (sIL-2R) levels have been
       reported in the sera from HIV-1 seropositive individuals. In this study,
       we determined plasma sIL-2R levels of seropositives every two to three
       months and investigated their relation to the clinical stages and virus
       isolation. METHODS: Heparinized bloods were obtained and separated into
       plasma and PBMCs. Plasma were used to quantitate the sIL-2R using ELIZA
       (T cell diagnostic Inc.). PBMCs were used for viral isolation. RESULTS:
       In four HIV-1 seropositives whose clinical stages progressed during this
       study, we recognized that sIL-2R was transiently elevated (> or = x 1.5)
       before disease progression. Next, we compared the sIL-2R levels with the
       period required for HIV-1 isolation. We found the correlations between
       them. As sIL-2R level was higher, the viral isolation was delayed in
       each individual. CONCLUSION: Precise observations of plasma sIL-2R
       levels were important to predict the disease progression of
       seropositives.
 DE    Biological Markers/*BLOOD  Enzyme-Linked Immunosorbent Assay/METHODS
       Human  HIV Seropositivity/*BLOOD/IMMUNOLOGY  *HIV-1
       Lymphocytes/IMMUNOLOGY  Predictive Value of Tests  Receptors,
       Interleukin-2/*ANALYSIS  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).