Document 3089
 DOCN  M94A3089
 TI    Predictive value of symptomatic primary acute HIV-1 infection: a two
       years evaluation following contamination.
 DT    9412
 AU    Derancourt C; el M'Rini T; Borne MC; Drobacheff C; Vuitton D; Leroy J;
       Portier H; Laurent R; Department of Dermatology and Cellule Sida,
       University Hospital,; Besancon, France.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):156 (abstract no. PB0051). Unique
       Identifier : AIDSLINE ICA10/94369486
 AB    OBJECTIVE: To determine, two years following contamination, the
       predictive value of symptomatic primary HIV 1 infection (CDC
       classification, CD4 cells count) compared to asymptomatic
       seroconversion, in a retrospective study. METHODS: Two cohorts including
       993 HIV 1 infected patients (1985-1994) were studied: Eleven patients
       with a primary symptomatic HIV 1 infection were observed; Seventeen
       patients seroconverted for HIV 1 within one year without any symptom.
       These two groups were compared two years following contamination in
       terms of CDC classification and CD4 cells count. RESULTS: No difference
       in CDC classification was found between the two groups. Symptomatic
       seroconverters: II: 4; III: 4; IVC2: 2; IVC1: 1; dead: 1 (two patients
       with one month duration fever had a rapid progression of the disease);
       Asymptomatic seroconverters: II: 6; III: 7; IVC2: 2; IVC1: 2. No
       difference in CD4 cells count was found between symptomatics
       (481/microliter; +/- SD = 279) and asymptomatics (441/microliter; +/- SD
       = 258). CONCLUSION: Previous long term studies disclosed a predictive
       value of symptomatic seroconversion in rapid progression of the disease.
       Our study doesn't reveal any difference (CDC classification, CD4 cells
       count) between symptomatic and asymptomatic patients, two years after
       contamination.
 DE    Acquired Immunodeficiency Syndrome/*CLASSIFICATION/IMMUNOLOGY/
       PHYSIOPATHOLOGY  Centers for Disease Control and Prevention (U.S.)
       Cohort Studies  Comparative Study  Human  HIV
       Seropositivity/*CLASSIFICATION/IMMUNOLOGY/PHYSIOPATHOLOGY  *HIV-1
       Leukocyte Count  Predictive Value of Tests  Retrospective Studies  Time
       Factors  T4 Lymphocytes  United States  MEETING ABSTRACT

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